Publications by authors named "Anyuli Gracia-Gutierrez"
: Heart failure (HF) is usually accompanied by other comorbidities, which, altogether, have a major impact on patients and healthcare systems. Our aim was to analyse the demographic and clinical characteristics of incident HF patients and the effect of comorbidities on one-year health outcomes. : This was an observational, retrospective, population-based study of incident HF patients between 2014 and 2018 in the EpiChron Cohort, Spain.
View Article and Find Full Text PDFBackground: We aimed to characterise and compare the clinical profile of heart failure (HF) with mid-range (HFmrEF), reduced (HFrEF) and preserved (HFpEF) left-ventricular ejection fraction.
Methods: We conducted a descriptive, observational study in 267 HF patients admitted to the Internal Medicine department of a tertiary hospital during 2010-2016. The study population was divided into three groups according to the ejection fraction rate: HFrEF (<40%), HFmrEF (40-49%), and HFpEF (≥50%).
Background: The WHO ordinal severity scale has been used to predict mortality and guide trials in COVID-19. However, it has its limitations.
Objective: The present study aims to compare three classificatory and predictive models: the WHO ordinal severity scale, the model based on inflammation grades, and the hybrid model.
Background: Cardiac involvement is common in amyloidosis, and the vast majority of cases of amyloid cardiomyopathy are attributed to primary amyloidosis or transthyretin amyloidosis (ATTR). Although the coexistence of scintigraphy suggestive of ATTR with monoclonal gammopathy of undetermined significance is well documented, the correct diagnosis is still challenging in non-referral centers.
Methods: We performed a retrospective study reviewing all amyloid cardiomyopathy cases diagnosed at our center over the last 5 years, and described our experience and diagnostic approach.
Uncontrolled inflammation following COVID-19 infection is an important characteristic of the most seriously ill patients. The present study aims to describe the clusters of inflammation in COVID-19 and to analyze their prognostic role. This is a retrospective observational study including 15,691 patients with a high degree of inflammation.
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- The study investigates how echocardiography can help identify cardiac amyloidosis (CA) in patients with left ventricular hypertrophy (LVH) who are experiencing heart failure (HF) decompensation.
- Out of 85 patients, 49 were diagnosed with CA, with specific echocardiographic measurements showing significant differences between those with CA and those without.
- Key features associated with CA included increased interventricular septum thickness, reduced left ventricular cavity size, and altered right ventricular function, emphasizing the role of echocardiography in diagnosing this condition.
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality.
View Article and Find Full Text PDF•We present a patient in whom myoclonus appeared after initiation of treatment with amoxicillin-clavulanic acid.•Myoclonus and EEG abnormalities disappeared after discontinuation of antibiotic treatment.•This possible adverse effect should be considered to avoid performing aggressive therapeutic maneuvers.
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- Heart failure (HF) is increasingly common and affects both sexes, but women are often underrepresented in clinical trials.
- A study analyzing 17,516 HF patients in Aragón, Spain found women to be older and at a lower risk of one-year mortality compared to men, despite both having similar disease burdens.
- Notably, men received more invasive treatments and hospital visits, while women's comorbidities and medications were often different, indicating the need for sex-specific HF management guidelines.
Article Synopsis
- The study aimed to analyze the comorbidities associated with heart failure (HF) in both men and women, focusing on their patterns and how these affect hospitalisation and mortality risks.
- Conducted in Aragón, Spain, the research utilized electronic health records from over 14,000 HF patients to identify prevalent chronic diseases and their clustering into six specific multimorbidity patterns.
- Findings showed that nearly all HF patients had multiple chronic conditions, with distinct patterns linked to varying levels of hospitalisation and mortality risk, highlighting the importance of understanding these patterns for better patient management.
Article Synopsis
- Transthyretin amyloidosis (ATTR) can be classified into wild-type (ATTR-wt) and hereditary forms (ATTR-m), with hereditary cases showing autosomal dominant inheritance.
- ATTR is often underdiagnosed but is becoming recognized as a significant cause of heart failure, particularly with preserved ejection fraction.
- A study evaluated High-Resolution Melting (HRM) analysis for detecting TTR mutations in patients suspected of having ATTR-m, finding it to be an effective and accurate diagnostic method, aligning 100% with TTR gene sequencing results.
Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease characterised by extracellular deposition of amyloid fibrils composed by transthyretin. ATTR amyloidosis can be sub-classified as wild-type ATTR (ATTR-wt) or as hereditary amyloidosis (ATTR-m); the prevalence of both types are likely underestimated. There are tools that can help us to study ATTR-m, as gnomAD database.
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