Publications by authors named "Anyela Lozano-Parra"
Chikungunya virus infection (CHIKV) increases the risk of persistent arthralgia; however, there is no consistent evidence regarding prognostic biomarkers of progression to chronic arthropathy. This systematic review provides an overview of currently available literature about the potential role of the acute immunologic response in predicting long-term joint pain in patients with a diagnosis of CHIKV. We searched for observational studies using the terms "chikungunya," "cytokines," "biomarkers," and "joint pain" in PubMed/MEDLINE, LILACS, Cochrane Library Plus, and SCOPUS databases, restricting to articles published in English and up to April 2024.
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- The study examined the long-term effects of chikungunya virus (CHIKV) infection, focusing on the incidence of post-chikungunya chronic rheumatism (pCHIK-CR) and its effects on quality of life (QoL) and chronic fatigue seven years after an outbreak in Piedecuesta, Colombia.
- Among 78 adults evaluated, 14.1% were found to have pCHIK-CR, 41.0% had non-inflammatory pain, and 44.9% had no rheumatic disease, with those suffering from pCHIK-CR showing the worst QoL and highest levels of chronic fatigue.
- The findings indicate that roughly one in seven individuals with CHIKV infection
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Infectious disease (ID) cohorts are key to advancing public health surveillance, public policies, and pandemic responses. Unfortunately, ID cohorts often lack funding to store and share clinical-epidemiological (CE) data and high-dimensional laboratory (HDL) data long term, which is evident when the link between these data elements is not kept up to date. This becomes particularly apparent when smaller cohorts fail to successfully address the initial scientific objectives due to limited case numbers, which also limits the potential to pool these studies to monitor long-term cross-disease interactions within and across populations.
View Article and Find Full Text PDFThe 2015-17 Zika virus (ZIKV) epidemic in the Americas subsided faster than expected and evolving population immunity was postulated to be the main reason. Herd immunization is suggested to occur around 60-70% seroprevalence, depending on demographic density and climate suitability. However, herd immunity was only documented for a few cities in South America, meaning a substantial portion of the population might still be vulnerable to a future Zika virus outbreak.
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- The study investigates the link between dietary patterns and flaviviral infections, specifically focusing on children during a Zika outbreak in a dengue-endemic region of Colombia.
- Researchers followed 424 children aged 2 to 12 over a year to see how adherence to different dietary patterns impacted their risk of developing anti-flavivirus IgG antibodies.
- Findings revealed that following a traditional dietary pattern, particularly including potatoes and sugarcane water, was associated with a higher risk of seroconversion, indicating a potential influence of diet on flaviviral infection responses.
Background: Saliva samples may be an easier, faster, safer, and cost-saving alternative to NPS samples, and can be self-collected by the patient. Whether SARS-CoV-2 RT-qPCR in saliva is more accurate than in nasopharyngeal swaps (NPS) is uncertain. We evaluated the accuracy of the RT-qPCR in both types of samples, assuming both approaches were imperfect.
View Article and Find Full Text PDFPopulation based serological surveys are the gold-standard to quantify dengue (DENV) transmission. The purpose of this study was to estimate the age-specific seroprevalence and the force of infection of DENV in an endemic area of Colombia. Between July and October 2014, we conducted a household based cross-sectional survey among 1.
View Article and Find Full Text PDFObjective: To estimate the age-specific incidence of symptomatic dengue and chikungunya in Colombia.
Method: A passive facility-based fever surveillance study was conducted among individuals with undifferentiated fever. Confirmatory diagnostics included serological and molecular tests in paired samples, and surveillance's underreporting was assessed using capture-recapture methods.
PUFA might modulate inflammatory responses involved in the development of severe dengue. We aimed to examine whether serum PUFA concentrations in patients diagnosed with dengue fever (DF) were related to the risk of progression to dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). A secondary aim was to assess correlations between fatty acids (FA) and inflammatory biomarkers in patients with DF.
View Article and Find Full Text PDFIntroduction: Dengue is the most important mosquito-borne infection in the world. There is evidence supporting the use of biochemical alterations as prediction tools for severity of illness in dengue.
Objective: To evaluate biochemical alterations as potential prediction markers for severity in dengue.