Fisetin attenuates AlCl-induced neurodegeneration by modulating oxidative stress and inflammatory cytokine release in adult albino wistar rats.

Aim: Natural flavonoids have powerful antioxidant and anti-inflammatory activities against neurodegenerative diseases. Fisetin is a powerful flavonoid that targets a variety of neurological disorders. Aluminum (Al) has been linked to several neurological conditions, such as Parkinsons disease, autism, and Alzheimer's disease (AD).

Incidentalomas in Chest Radiograph of Apparently Healthy Individuals Presenting for Pre-Employment Medical Examination in Enugu State, Nigeria.

Background: A chest radiograph is the most commonly requested and performed imaging for diagnosis and screening including medical examination.

Aim: The study aimed to determine the prevalence and pattern of incidentalomas in radiographs of cases presenting for pre-employment medical examination.

Methods: This was a retrospective review of chest radiographs conducted for patients presenting for pre-employment medical examination from January to December 2022.

Cholinergic Inhibition and Antioxidant Potential of Gongronema latifolium Benth Leaf in Neurodegeneration: Experimental and In Silico Study.

The use of Gongronema latifolium for the management of various forms of neurological disorders has generated a lot of interest in the need to further investigate its neurotherapeutic constituents. This work, therefore, focused on assessing the inhibitory potential of selected bioactive components derived from G. latifolium against key neurotherapeutic targets and oxidant species associated with neurodegeneration using in vitro analysis and biomolecular modelling.

Targeting cholinergic and endocannabinoid system as a therapeutic intervention for core asd associated phenotypes in autism model: a systematic review.

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has been linked to the dysregulation in the cholinergic and endocannabinoid (EC) system. This study systematically reviews the present literature on treatment strategies aimed at enhancing the activity of both systems in ASD models.

Method: We performed a systematic evaluation of literatures that investigated the effects of different therapeutic interventions on the components of the cholinergic and EC systems in ASD models, following the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK signaling pathway.

Curcumin, a bioactive polyphenol derived from turmeric, has been reported to have anti-inflammatory properties. The current study investigated the anti-inflammatory effect of curcumin in the hippocampal subfields (CA1 and CA3) after exposure to cobalt (Co) and the impact of ERK protein. Twenty-eight albino Wistar rats were divided into four groups, each with seven randomly selected rats as follows: Control (distilled water), Cobalt (Co) only (40 mg/kg), 120 mg/kg or 240 mg/kg curcumin + Co (40 mg/kg).

Phytochemical analysis, in vitro and in silico effects from Alstonia boonei De Wild stem bark on selected digestive enzymes and adipogenesis in 3T3-L1 preadipocytes.

Background: Obesity is a global health issue arising from the unhealthy accumulation of fat. Medicinal plants such as Alstonia boonei stem bark has been reported to possess body weight reducing effect in obese rats. Thus, this study sought to investigate the in vitro and in silico effects of fractions from Alstonia boonei stem bark on selected obesity-related digestive enzymes and adipogenesis in 3T3-L1 preadipocytes.

Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated computational analysis.

Neurodegenerative disorders (NDDs) are associated with increased activities of the brain acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-secretase enzyme (BACE1). Inhibition of these enzymes affords therapeutic option for managing NDDs such as Alzheimer's disease (AD) and Parkinson's disease (PD). Although, Gongronema latifolium Benth (GL) has been widely documented in ethnopharmacological and scientific reports for the management of NDDs, there is paucity of information on its underlying mechanism and neurotherapeutic constituents.

Modulatory Role of Curcumin on Cobalt-Induced Memory Deficit, Hippocampal Oxidative Damage, Astrocytosis, and Nrf2 Expression.

Chemical overexposure is a growing environmental risk factor for many medical issues. Cobalt toxicity from environmental, industrial, and medical exposure has previously been linked to neurological impairment. Hence, the current study looked into the neuroprotective potential of curcumin, a natural polyphenol contained in the spice turmeric, against cobalt-induced neurotoxicity.

Morphometric study of post menarcheal nulliparous breasts, their clinical relevance and relationship with body size indicators in a Nigerian population.

Background: The female breast is a symbol of femininity and aesthetics having a great psychosocial impact on the woman's sense of wellbeing and self-esteem. To optimize satisfaction of patients in cosmetic and reconstructive breast surgeries, there is a need to define the dominant breast size and shape that connotes feminine attractiveness. This necessitates the knowledge of ideal data for normal nulliparous female breast parameters and volume for various body sizes in the particular population, nationality, and race.

Optimum inclusion levels of Leucaena leucocephala pasture leaf-meal on growth, haematology and physiological performance of growing pigs.

This study was conducted to evaluate the optimum inclusion levels of Leucaena leucocephala leaf meal on growth, haematology, and physiological performance of pigs. A total of 16 grower pigs comprising of 12 females and 4 castrated males weighing an average of 13.5 kg were assigned into a completely randomized experimental layout, subjected to 4 inclusion levels of leaf meal (0, 50, 100, and 150 g/kg DM).

Reference indices for evaluating kidney dimensions in children using anthropometric measurements.

Background: Kidney pathologies often result in change in renal size. Knowledge of normal kidney sizes is important for screening, diagnosis, prognosis and follow-up management of paediatric renal diseases.

Objectives: The aim of this study was to establish the age-, height- and weight-matched kidney dimensions in apparently healthy Nigerian children.

Pharmacological activities of a novel phthalic acid ester and iridoid glycoside isolated from the root bark of Anthocleista vogelii Planch.

In this study, a novel phthalic acid ester (1) and a known iridoid glycoside (2) were isolated from the root bark of Anthocleista vogelii. The structures of the novel compound and iridoid glycoside were elucidated on the basis of their chemical and spectral data (UV, FT-IR, EI-MS, 1D and 2D NMR) and found to be phthalic acid ester, 4-ethyl-6-propyl-4,5,6,7-tetrahydro3H-2,8-benzodioxacycloundecine-1,9-dione (1) and sweroside (2). The compounds were evaluated for their in vitro inhibitory activities against pancreatic lipase, α-amylase and αglucosidase, and in vivo laxative activity in rats.

Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes.

Ethnopharmacological Relevance: Anthocleista vogelii Planch is a medicinal plant traditionally used in West Africa for the management and treatment of diabetes mellitus.

Aim Of The Study: To determine the antidiabetic activities of chloroform fraction (CF) of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes.

Materials And Methods: Inhibitory activities of CF against α-amylase and α-glucosidase activities were determined in vitro.

Prevalence, pattern and correlates of work-related musculoskeletal disorders among school teachers in Enugu, Nigeria.

. There is insufficient literature on the prevalence of and risk factors for work-related musculoskeletal disorders (MSDs) among teachers in Nigeria. This study aimed to investigate the prevalence of work-related MSDs and their associations with occupational and socio-demographic factors of Nigerian-based school teachers.

Prevalence and associated factors of work related musculoskeletal disorders among commercial milling machine operators in South-Eastern Nigerian markets.

Background: Milling machine operators perform physically demanding tasks that can lead to work related musculoskeletal disorders (WRMSDs), but literature on WRMSDs among milling machine operators is scarce. Knowledge of prevalence and risk factors of WRMSDs can be an appropriate base for planning and implementing ergonomics intervention programs in the workplace.

Objective: This study aimed to determine the prevalence, pattern and associated factors of WRMSDs among commercial milling machine operators in Enugu, Nigeria.

Infant carrying methods: Correlates and associated musculoskeletal disorders among nursing mothers in Nigeria.

Infant carrying is an integral part of the mothering occupation. Paucity of data exists on its correlates and associated musculoskeletal injuries. In this study, factors and musculoskeletal injuries associated with infant carrying were investigated in 227 nursing mothers, using a structured questionnaire.

Musical preferences and learning outcome of medical students in cadaver dissection laboratory: A Nigerian survey.

Background music has been reported to enhance learning in the cadaver dissection laboratory. This study was designed to determine the impact of various forms of musical genre and some of their characteristics on students' learning outcome in the dissection laboratory. Some selected musical genre in vocal and non-vocal forms and at different tempi and volume were played as background music (BM) to 253 Medical and Dental students during various sessions of cadaver dissection.

Impact of overweight and obesity on the musculoskeletal system using lumbosacral angles.

Background: Overweight and obesity have been identified as independent risk factors for musculoskeletal disorders. However, the association between obesity and low back pain remains controversial. Little is known about the effects of overweight and obesity on the angles of the lumbosacral spine.

Medicinal plants of the genus Anthocleista--A review of their ethnobotany, phytochemistry and pharmacology.

Ethnopharmacological Relevance: The genus Anthocleista of the Gentianaceae family contains 14 species of trees and shrub-like plants distributed in tropical Africa, in Madagascar and on the Comoros. Traditionally, they are commonly used in the treatment of diabetes, hypertension, malaria, typhoid fever, obesity, diarrhea, dysentery, hyperprolactinemia, abdominal pain, ulcer, jaundice, asthma, hemorrhoids, hernia, cancer, wounds, chest pains, inflammations, rheumatism, STDs, infertility and skin diseases. They serve as an anthelmintic, laxative, diuretic and contraceptive.

Use of fetal biometry in the assessment of gestational age in South East Nigeria: Femur length and biparietal diameter.

Background: Fetal growth is influenced by many factors such as race, socioeconomic status, genetics, geographical location, maternal diseases, and number of babies. Consequent upon these, fetal growth charts may vary from one location to another even within the same geographical entity.

Objective: This study was designed to establish the fetal growth chart in antenatal women who had ultrasound scanning at the University of Nigeria Teaching Hospital, Enugu, South East Nigeria.

Sonographic assessment of the normal limits of the spleen in healthy school children in South-East Nigeria.

Background/objective: Ultrasonogrphy is a good modality for the detection of splenomegaly even when it is not clinically palpable. The objective of this study was to establish the normal values of splenic length in healthy school children in South-East, Nigeria and to correlate them with body indices.

Materials And Methods: This is a cross-sectional prospective study of 1315 children (633 boys and 682 girls) between the ages of 5 and 17 years.

Mechanisms of hip fracture in owerri, Nigeria, and its associated variables.

Background: Hip fracture has been associated with various risk factors, including osteoporosis, excessive alcohol consumption, physical inactivity, visual impairment, aging, sex, rural/urban inhabitation, race and climatic variations. Mechanisms of hip fractures in many parts of the world have been documented, and include road traffic accident (RTA), gunshot injury, fall from heights and many others. There is paucity of such documentation in Owerri, Nigeria.

Macro-biophysical properties of candidate novel feedstuffs for poultry feeding.

Information on the proximate composition and sometimes the toxicology of novel feedstuffs has been used routinely in determining the suitability of feedstuffs in poultry feeding, especially during animal feeding trials. Limited information however exists on the biophysical characteristics of such novel feedstuffs. The Bulk Density (BD), Water-holding Capacity (WHC) and Specific Gravity (SG) of three novel feedstuffs {Leaf Meal (LEM), Rumen Digesta (RD) and Poultry Dung (PD)}, were evaluated.