A turn on fluorescent probe for nitroreductase activity and its application in real-time imaging of tumor hypoxia.

Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors, with its levels closely correlated to the degree of hypoxia. This correlation has significant clinical implications for the analysis of tumor hypoxia, as it allows for the indirect detection of nitroreductases. Due to their simplicity, noninvasive nature, and excellent spatiotemporal resolution, various fluorescence methods have been developed for the analysis of nitroreductase and tumor hypoxia.

In-Site Boron Doping Microenvironmental Modulation toward Recyclable SAPO-11 for Efficient Beckmann Rearrangement of Cyclohexanone Oxime.

In the research of gas-phase Beckmann rearrangement reactions, the employment of modified molecular sieve catalysts has garnered significant research attention. However, the prevalent supported molecular sieve catalysts currently face two formidable challenges. First, the loaded catalytic species are susceptible to detachment, compromising the catalyst's stability over time.