Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway.

Aims: Bladder outlet obstruction (BOO) and the consequent low contractility of detrusor are the leading causes of voiding dysfunction. In this study, we aimed to evaluate the pharmacological activity of astragaloside IV (AS-IV), an antioxidant biomolecule that possess beneficial effect in many organs, on detrusor contractility and bladder wall remodeling process.

Methods: Partial BOO (pBOO) was created by urethral occlusion in female rats, followed by oral gavage of different dose of AS-IV or vehicle.

[Effects of Kudzu Root plus Cinnamon Granules on prostatic hyperplasia in mice].

Objective: To explore the effects of Kudzu Root plus Cinnamon Granules (KR+C) on prostatic hyperplasia (PH) in mice.

Methods: Sixty 4-week-old Kunming male mice were randomly divided into six groups: blank control, PH model, high-, medium- and low-dose KR+C, and finasteride control. All the mice except those in the blank control group were subcutaneously injected with testosterone propionate (5 mg / ［kg·d］) at 7 days after surgical castration.

[Cryosurgical ablation for aged patients with severe benign prostate hyperplasia: a report of 21 cases].

Objective: To study the clinical effect of cryosurgical ablation for aged patients with severe benign prostate hyperplasia.

Methods: Twenty-one 72-91-year-old patients with severe benign prostate hyperplasia accompanied with cardiopulmonary dysfunction were treated by the ENDOCARE cryo-care surgery system with cryo-probes guided by type B ultrasound. Observations were made of the post-operation prostate biopsy and ultrasonogram as well as the changes of the urinary flow rate (UFR) and prostate-specific antigen (PSA).