Publications by authors named "Anxela Vidal-Gonzalez"
Article Synopsis
- Whole-body autopsies of 70 COVID-19 patients were conducted to explore the disease's pathophysiology and the impact of superinfections.
- The average age of the subjects was 70, with most having pre-existing health issues; 65.71% experienced infectious complications during their hospitalization, and invasive mechanical ventilation was common.
- Key autopsy findings included severe lung damage, heart conditions, and liver issues, highlighting the significant roles of comorbidities and superinfections in COVID-19 pathology.
Background: Sigh is a cyclic brief recruitment maneuver: previous physiologic studies showed that its use could be an interesting addition to pressure support ventilation to improve lung elastance, decrease regional heterogeneity, and increase release of surfactant.
Research Question: Is the clinical application of sigh during pressure support ventilation (PSV) feasible?
Study Design And Methods: We conducted a multicenter noninferiority randomized clinical trial on adult intubated patients with acute hypoxemic respiratory failure or ARDS undergoing PSV. Patients were randomized to the no-sigh group and treated by PSV alone, or to the sigh group, treated by PSV plus sigh (increase in airway pressure to 30 cm HO for 3 s once per minute) until day 28 or death or successful spontaneous breathing trial.
The spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the histological basis for these disorders has not been thoroughly explored. Post-mortem pulmonary and bone marrow biopsies were performed in 33 patients. Samples were studied with a combination of morphological and immunohistochemical techniques.
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