Aging-related early changes in markers of ventricular and matrix remodeling after reperfused ST-segment elevation myocardial infarction in the canine model: effect of early therapy with an angiotensin II type 1 receptor blocker.

Background: Elderly patients with reperfused ST-segment-elevation myocardial infarction are at increased risk for left ventricular remodeling. Extracellular matrix damage has been implicated in early remodeling. We hypothesized that aging results in enhanced early reperfusion injury and left ventricular remodeling after reperfused ST-segment-elevation myocardial infarction and that early therapy initiated at the time of reperfusion with an angiotensin II type 1 receptor blocker such as candesartan attenuates age-related increases in reperfusion injury and remodeling.

STEMI and heart failure in the elderly: role of adverse remodeling.

The elderly population (age > or = 65 years) has been increasing worldwide. In North America and Europe, both heart failure (HF) and ST-segment elevation MI (STEMI) are more prevalent in the elderly. Morbidity, hospitalizations and costs associated with HF are higher in the elderly.

Oxygen uptake kinetics: associations with ambulatory activity and physical functional performance in stroke survivors.

Objective: To explore the associations amongst the on-and-off kinetics time constants, ambulatory activity outcomes, and physical functional performance in stroke survivors.

Design: Cross-sectional, case control study.

Subjects: Ten stroke survivors (time since stroke: mean 7.

Use of the continuous scale physical functional performance test in stroke survivors.

Objective: To (1) determine the feasibility of the continuous scale physical functional performance 10-item test (CS-PFP10) for the measurement of physical function in stroke survivors, (2) characterize physical functional performance of stroke survivors and their matched controls, and (3) explore the associations among physical functional performance, ambulatory activity, and peak oxygen uptake (VO2peak).

Design: Case control.

Setting: University research setting.

Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients.

The cardiovascular response to exercise in heart transplant recipients (HTR) has been compared with that of healthy individuals matched to the recipient age (RM controls). However, no study has compared HTR with donor age-matched (DM) controls. Moreover, the cardiovascular response to sustained submaximal exercise in HTR requires further evaluation.

Cardiac reserve and pulmonary gas exchange kinetics in patients with stroke.

Background And Purpose: Cardiovascular and pulmonary factors contributing to impaired peak oxygen uptake (VO2) in patients with stroke (SP) are not well known. We assessed cardiovascular function, pulmonary gas exchange, and ventilation in SP and healthy age, gender, and activity-matched control subjects.

Methods: Ten hemiparetic SP and 10 control subjects were enrolled.