Publications by authors named "Anusha Mithani"
Behav Brain Res
October 2021
Article Synopsis
- Obesity is influenced by multiple factors, including genetic, environmental, and endocrine elements, with rare monogenic forms necessitating the study of other contributing mechanisms.
- Methyl-Cp-G binding protein 2 (MeCP2) plays a role in obesity by binding to DNA and affecting gene transcription, with past studies indicating its disruption leads to obesity in mice.
- In a mouse model of diet-induced obesity, perinatal exposure to a high-fat diet significantly reduced MeCP2 expression in the hypothalamus, showing sex-specific patterns in expression changes, while suggesting that high-fat diet exposure in adulthood may affect different mechanisms unrelated to MeCP2.
