Assessment of drought with a real-time web-based application for drought management in humid tropical Kerala, India.

Geospatial techniques are useful for near real-time monitoring of drought and towards devising local-level effective drought management plan. Based on the historic and current remote sensing data, one can identify the influence of drought on the vegetation status by analyzing the anomaly/drought condition of a particular area of interest (AOI) through different digital image processing techniques. In this study, an attempt has been made to develop a web-based application for generating drought maps and district-wise drought information at real time in the web server using Hypertext Preprocessor (PHP) and Python scripts.

Mechanism of protection of rat hepatocytes from acetaminophen-induced cellular damage by ethanol extract of .

The aim of this study is to evaluate the protective effect of ethanol extract of (EEAL) in preventing acetaminophen induced liver toxicity. EEAL was prepared and its hepatoprotective effect was studied in both isolated primary hepatocytes and in Sprague Dawley rats . For studies, the animals were grouped as Group I - Control; Group II - ACN (2 g/kg b.

Impact of practice modification on oral health status of students: An interventional study from a tribal area of India.

Context: Tooth decay precipitated by poor oral hygiene is one of the most common oral diseases that affect 60-90% of school children. It not only interferes with speech, self-esteem but pain caused by decay also affects nutrition intake, resulting in malnutrition with abnormal cognitive development.

Aim: To evaluate the impact of health education and supervised brushing intervention on their oral health status.

Effect of Transition Metal Fragments on the Reverse Fritsch-Buttenberg-Wiechell Type Ring Contraction Reaction of Metallabenzynes to Metal-Carbene Complexes.

Metallabenzynes (1M), contrary to their organic analogues, benzynes, undergo ring-contraction to metal-carbene complexes (2M) via a reverse Fritsch-Buttenberg-Wiechell (FBW) type rearrangement. A detailed computational quantum mechanical study has been carried out to understand the effect of different third row transition metal fragments (MLL'; M = W, Re, Os, Ir, Pt; L/L' = PH, Cl, CO) on the stability of metallabenzynes and their reactivity toward reverse FBW type rearrangement. Our results indicate that the late transition metal fragments Ir(PH)Cl and PtCl prefer 16 VE metal-carbene complex (2M), while the middle transition metal fragments W(PH), Re(PH)Cl, and Os(PH)Cl prefer metallabenzyne (1M).

Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase.

Objectives: Copper oxide nanoparticles (CuO NPs) promoting anticancer activity may be due to the regulation of various classes of histone deacetylases (HDACs).

Results: Green-synthesized CuO NPs significantly arrested total HDAC level and also suppressed class I, II and IV HDACs mRNA expression in A549 cells. A549 cells treated with CuO NPs downregulated oncogenes and upregulated tumor suppressor protein expression.

Ring contraction of metallabenzooxirene to metal carbonyl complexes - a comparative study with the Wolff rearrangement of oxirene and benzooxirene.

A detailed quantum mechanical study on the role of transition metal fragments towards the epoxidation reaction of metallabenzynes (1M, M = Fe, Ru, Os) to give metallabenzyne epoxide or metallabenzooxirene (2M), followed by the Wolff type 1,2-rearrangement to give metal carbonyls (4M), has been carried out at the M06/def2-TZVPP//BP86/def2-SVP level of theory. The epoxide or oxirene product (2A) of linear alkynes like acetylene is unstable and converts to a ketene (4A) by highly exothermic (-78.7 kcal mol) Wolff rearrangement via an oxocarbene (3A) intermediate.

Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra which is associated with oxidative stress, neuroinflammation and apoptosis. Apigenin (AGN), a non-mutagenic flavone found in fruits and vegetables, exhibits a variety of biological effects including anti-apoptotic, anti-inflammatory, and free radical scavenging activities. The current study was aimed to investigate the neuroprotective effects and molecular mechanisms of AGN in a rat model of PD induced by rotenone (ROT).

Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line.

Histone deacetylases (HDACs) are a group of epigenetic enzymes that control gene expression through their repressive influence on histone deacetylation transcription. HDACs are probable therapeutic targets for cancer treatment, spurring the progress of different types of HDAC inhibitors. Further, natural-source-based derived bioactive compounds possess HDAC inhibitor property.

Evaluation of Two Facebow/Semi-adjustable Articulator Systems for Orienting Maxillary Cast on Articulators: A Pilot Study.

Aim: The present study was aimed to assess the transferability of occlusal plane (OP) orientation from the patient to the articulators with the help of two different facebow systems and evaluated with a gold standard.

Materials And Methods: Twenty dentate patients were selected for the study. Two semi-adjustable arcon articulators that are Hanau Wide(®) Vue using SpringBow and Whip Mix(®) using quick-mount facebow were used in the study.

An Aluminum Hydride That Functions like a Transition-Metal Catalyst.

The reaction of [LAlH2 ] (L=HC(CMeNAr)2 , Ar=2,6-iPr2 C6 H3 ) with MeOTf (Tf=SO2 CF3 ) resulted in the formation of [LAlH(OTf)] (1) in high yield. The triflate substituent in 1 increases the positive charge at the aluminum center, which implies that 1 has a strong Lewis acidic character. The excellent catalytic activity of 1 for the hydroboration of organic compounds with carbonyl groups was investigated.

Variation in Size and Form between Left and Right Maxillary Central Incisor Teeth.

Background: To compare the variation in size of left and right maxillary central incisors for male patients (using digital calipers of 0.01 mm accuracy). To compare the variation in size of left and right maxillary central incisors for female patients (using digital calipers of 0.

Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species.

NF-κB signalling is one of the main cell survival pathways that attenuate the anticancer efficacy of therapeutic drugs. Previous studies demonstrated that the histone deacetylase (HDAC) inhibitor induces apoptosis in some malignancies through multiple mechanisms including up-regulation of death receptors, disruption of Hsp90 function and generation of reactive oxygen species (ROS). However, HDAC inhibitor also induces a cell survival signal through NF-κB activation.

Drought risk mapping of south-western state in the Indian peninsula - A web based application.

Application of geospatial technology is very shimmering in drought monitoring. Drought severity in crops for six northern districts of Kerala has been attempted using Geospatial Techniques. Normalized Difference Vegetation Index (NDVI) is the major parameter used to measure vegetation health obtained from MODIS, Terra satellite products MOD13Q1, MOD02QKM.

Ring contraction of six-membered metallabenzynes to five-membered metal-carbene complexes: a comparison with organic analogues.

The ring contraction of six-membered metallabenzynes to five-membered metal-carbene complexes in comparison with the corresponding rearrangement of benzyne to cyclopentadienylidene carbene have been studied by computational quantum mechanical calculations. The rearrangement of benzyne to a cyclopentadienylidene carbene is endothermic by 27.8 kcal mol(-1).

Protective effect of Bacopa monniera on methyl mercury-induced oxidative stress in cerebellum of rats.

Methyl mercury (MeHg) is a ubiquitous environmental pollutant leading to neurological and developmental deficits in animals and human beings. Bacopa monniera (BM) is a perennial herb and is used as a nerve tonic in Ayurveda, a traditional medicine system in India. The objective of the present study was to investigate whether Bacopa monniera extract (BME) could potentially inhibit MeHg-induced toxicity in the cerebellum of rat brain.