H3F3A-mutated giant cell tumour of bone without giant cells-clinical presentation, radiology and histology of three cases.

Aims: Giant cell tumour of bone (GCTB) is histologically defined as a lesion containing reactive giant cells and a neoplastic mononuclear cell population; in up to 92% of cases, GCTB is characterised by a specific mutation of the histone gene H3F3A. The cellular composition ranges from giant-cell-rich to giant-cell-poor. The diagnosis of GCTB can be challenging, and several other lesions need to be excluded, e.

Patient-specific and intra-operatively modifiable factors assessed by computer navigation predict maximal knee flexion one year after TKA.

Purpose: There are multiple factors affecting maximal knee flexion (MKF) after total knee arthroplasty (TKA). The aim of the study was to investigate whether patient-specific factors (PSF) and surgically modifiable factors (SMF), measured by means of a computer-assisted navigation system, can predict the MKF after TKA.

Methods: Data from 99 patients collected during a randomized clinical trial were used for this secondary data analysis.

Do Well-Balanced Primary TKA Patients Achieve Better Outcomes Within the First Year After Surgery?

Some surgically modifiable factors are related to soft tissue balance. With computer-assisted surgery, it is possible to access these variables quantitatively. The aim of this analysis was to study the influence of gap balance on clinical outcomes within the first year after computer-navigated total knee arthroplasty (TKA).

Surgically modifiable factors measured by computer-navigation together with patient-specific factors predict knee society score after total knee arthroplasty.

Background: The purpose was to investigate whether patient-specific factors (PSF) and surgically modifiable factors (SMF), measured by means of a computer-assisted navigation system, can predict the Knee Society Scores (KSS) after total knee arthroplasty (TKA).

Methods: Data from 99 patients collected during a randomized clinical trial were used for this secondary data analysis. The KSS scores of the patients were measured preoperatively and at 4-years follow-up.

No differences in clinical outcomes between fixed- and mobile-bearing computer-assisted total knee arthroplasties and no correlations between navigation data and clinical scores.

Purpose: The theoretical advantages of mobile-bearing (MB) designs over the conventional fixed bearings (FBs) for total knee arthroplasty (TKA) have not been proved yet through clinical studies. The aim of the study was to test whether the MB design has advantages in terms of better clinical outcomes when compared to FB. Furthermore, the relationships between intra-operative obtained implant positioning data and the clinical scores were analysed.

One year after navigated total knee replacement, no clinically relevant difference found between fixed bearing and mobile bearing knee replacement in a double-blind randomized controlled trial.

Background: The mobile bearing designs have not yet been shown to improve clinical outcome of total knee arthroplasty (TKA). In this prospective randomized study, we compared the short-term clinical results of a mobile bearing implant with those of the fixed bearing version of the same implant.

Methods: We randomized 100 knees into two double-blind groups who received either the fixed (FB, 52 knees) or the mobile bearing (MB, 48 knees) version of the same implant.

Accuracy of implant alignment and early results after minimally invasive vs conventional OrthoPilot-navigated Columbus TKA.

The goal of this study was to evaluate potential risks and benefits of minimally invasive vs conventional approaches in navigated total knee arthroplasty (TKA) in 50 patients. Preoperatively, no statistically significant differences between the two groups were found for deformity, range of motion (ROM), clinical scores, and ligament stability in the native joint or after prosthesis implantation measurements intraoperatively. Postoperatively, there were no significant differences between the two groups for deformity and clinical scores.