A role of NLRP3 and MMP9 in migraine progression: a systematic review of translational study.

Background: Migraines affect one billion individuals globally, with a higher occurrence among young adults and women. A significant survey in the United States indicated that 17.1% of women and 5.

Acute and sub-chronic toxicity study of novel polyherbal formulation in non-alcoholic fatty liver using Wistar rats.

This study assessed the acute and sub-chronic toxicity of a novel polyherbal formulation tablet in Wistar rats Acute toxicity and sub-chronic toxicity was assessed following OECD (Organisation for the Economic Co-operation and Development) guidelines based on 423 and 408. No mortality and toxicity showed in rats during acute toxicity. The LD of the extract was at 2000 mg/kg.

Effect of Per and Poly-Fluoroalkyl Substances on Pregnancy and Child Development.

Background: Childhood obesity is significantly influenced by maternal exposure to Per- and Poly-Fluoroalkyl Substances (PFAS) during pregnancy. PFAS exposure occurs through the Peroxisome Proliferator-Activated Receptor (PPAR-γ) receptor, leading to increased fat deposition and profound health effects in child growth and development. Despite ongoing investigations, the relationship between maternal serum PFAS concentration and child obesity requires further exploration.

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model.

This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer's disease-like condition to enhance translational research. Our review seeks to understand how MSG affects the brain and causes degenerative disorders. Due to significant preclinical data linking glutamate toxicity to Alzheimer's disease and the lack of a comprehensive review or meta-analysis, we initiated a study on MSG's potential link.

GC-MS based metabolite profiling, antioxidant and antiurolithiatic properties of apple cider vinegar.

Aim: To perform analysis of antioxidant and antiurolithiasis to carry out GC-MS-based metabolite profile.

Materials & Methods: The effect of apple cider vinegar (ACV) , antioxidant and GC-MS analysis was evaluated. The antioxidant studies were performed.

Perspectives of ozone induced neuropathology and memory decline in Alzheimer's disease: A systematic review of preclinical evidences.

This systematic review aims to discover the plausible mechanism of Ozone in A.D., to boost translational research.

Computer Aided Drug Design Approach to Screen Phytoconstituents of as Potential Inhibitors of SARS-CoV-2 Main Protease Enzyme.

A novel coronavirus (COVID-19) was identified as one of the severe acute respiratory syndrome coronaviruses (SARS-CoV-2) and emerged as a pandemic in 2020. Thus, there is an urgent need to screen and develop an agent to suppress the proliferation of viral particles of SARS-CoV-2, and several drugs have entered clinical trial phases to assess their therapeutic potential. The objective of the present study is to screen phytochemicals against the main viral protease using molecular docking studies.