Phytochemical Repurposing of Natural Molecule: Sabinene for Identification of Novel Therapeutic Benefits Using and Approaches.

Repurposing of drugs/natural or synthetic chemicals is a promising approach to identify the new therapeutic indication/use and mode of action. In pharmaceuticals, this process is used to save the time and cost for the drug discovery process with reduced risk of failure. In the present studies, repurposing of a natural molecule: sabinene (major phytochemical in cardamom) was used to characterize the new biological activities using in silico in vitro In silico similarity searching demonstrated that (+)-3-carene possessed the maximum structural similarity with sabinene.

Phenotypic and genotypic methods for the detection of methicillin resistant coagulase negative staphylococci: a comparative study.

CONS are the major cause of nosocomial infection in last decade and methicillin resistant CoNS has emerged as a major clinical problem. The present study was to compare different phenotypic methods with genotypic method PCR, for the detection of methicillin resistance in CoNS. 100 CoNS isolates from different samples were studied for the detection of mecA gene.

Prevalence and antibiotic resistance pattern of metallo-beta-lactamase-producing Pseudomonas aeruginosa from burn patients--experience of an Indian tertiary care hospital.

The objective of the study is to determine the prevalence of Pseudomonas aeruginosa from burn patients, antibiotic resistance pattern and occurrence of acquired MBL-producing P. aeruginosa among isolates collected from burn patients. In this study, two phenotypic methods were used for the detection of MBL-producing P.

Phenotypic and genotypic methods for the detection of methicillin resistant coagulase negative staphylococci: a comparative study.

CoNS are the major cause of nosocomial infection in last decade and methicillin resistant CoNS has emerged as a major clinical problem. The present study was to compare different phenotypic methods with genotypic method PCR, for the detection of methicillin resistance in CoNS. 100 CoNS isolates from different samples were studied for the detection of mecA gene.

Atypical bacterial pathogens in community-acquired pneumonia in children: a hospital-based study.

A total of 243 children aged one month to five years with World Health Organization defined severe community acquired pneumonia were studied for the presence of atypical bacterial pathogens: 24 were found positive for mycoplasma infection. There was no significant association with any of the clinical, laboratory and radiological variables in children with pneumonia by the atypical pathogen.

Proteomic analysis of urinary protein markers for accurate prediction of diabetic kidney disorder.

Aim Of The Study: Microalbuminuria is currently the only diagnostic tool available for early diagnosis of diabetic nephropathy. The test is based on immunological detection of small quantities of albumin in the urinary samples of diabetes patients. There are several limitations of the use of microalbuminuria as an index of renal function.