Publications by authors named "Anuradha Jayasuriya"
Article Synopsis
- The study aims to improve the understanding of non-functioning pituitary microadenomas (micro-NFPAs) and their natural progression to inform patient care.
- Conducted across 23 endocrine departments in the UK, it analyzed clinical data from 459 patients over a median of 3.5 years, assessing tumor growth and hormonal changes.
- Results indicate a low probability of tumor growth (7.8% at 3 years) and rare development of hypopituitarism, suggesting that follow-up MRIs every 3 years and less frequent hormonal checks are adequate for managing micro-NFPAs.
Background: Gestational trophoblastic disease (GTD) which includes hydatidiform mole, invasive mole, placental site trophoblastic tumor, and choriocarcinoma is a rare cause of hyperthyroidism due to excess production of placental human chorionic gonadotrophin hormone (hCG) by tumor cells. Molecular mimicry between hCG and thyroid stimulating hormone (TSH) leads to continuous stimulation of TSH receptor by extremely high levels of hCG seen in these tumors. Consequently, biochemical and clinical hyperthyroidism ensues and it is potentially complicated by thyrotoxic crisis which is fatal unless urgent therapeutic steps are undertaken.
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