Geographical Distribution, Host Range and Genetic Diversity of f. sp. Causing Wilt of Banana in India.

wilt of banana is a major production constraint in India, prompting banana growers to replace bananas with less remunerative crops. Effective disease management practices thus need to be developed and implemented to prevent further spread and damage caused by f. sp.

Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy.

Diabetic Peripheral Neuropathy (DPN) is a nerve damage that is treated with painkillers and steroids which have the drawback of interference with other medications and the dangers of side effects. Novelty of the proposed work is to develop a Near Infrared Region (NIR) based non-invasive therapy device called 'DPNrelief-1.0V'developed with a 890 nm wavelength diodes.

Integrative hybrid deep learning for enhanced breast cancer diagnosis: leveraging the Wisconsin Breast Cancer Database and the CBIS-DDSM dataset.

The objective of this investigation was to improve the diagnosis of breast cancer by combining two significant datasets: the Wisconsin Breast Cancer Database and the DDSM Curated Breast Imaging Subset (CBIS-DDSM). The Wisconsin Breast Cancer Database provides a detailed examination of the characteristics of cell nuclei, including radius, texture, and concavity, for 569 patients, of which 212 had malignant tumors. In addition, the CBIS-DDSM dataset-a revised variant of the Digital Database for Screening Mammography (DDSM)-offers a standardized collection of 2,620 scanned film mammography studies, including cases that are normal, benign, or malignant and that include verified pathology data.

Coccinellid predators of mealybugs infesting banana in South India, including a new species and a new record of Scymnus Kugelann (Coleoptera: Coccinellidae), with notes on other natural enemies.

Several species of mealybugs infest various parts of bananas and plantains including foliage, fruits, rhizome and roots in all the major banana growing regions of India and cause moderate to occasionally serious damage but systematic attempts at documenting the mealybug pests of banana and their natural enemies are lacking in India. In this study, mealybugs infesting bananas and plantains in Tamil Nadu, South India, are documented along with their coccinellid predators and other natural enemies. The exotic Jack Beardsley mealybug, Pseudococcus jackbeardsleyi Gimpel & Miller, was found to be a major pest of banana bunches in all localities surveyed in Tamil Nadu and the grey pineapple mealybug, Dysmicoccus neobrevipes Beardsley, was a serious pest in some isolated pockets.

Dataset from transcriptome profiling of resistant and susceptible cultivars in response to f.sp. race1 and TR4 challenges using Illumina NovaSeq.

In this investigation, the study focused on the RNAseq data generated in response to f.sp. (Foc) race1 (Cavendish infecting strain VCG 0124), targeting both resistant (cv.

Molecular characterization of Red banana and its somaclonal variant: a comprehensive study.

Unlabelled: The prized Red banana, selected for superior qualities, demands strong genetic uniformity for successful clonal propagation and preservation. Ensuring this uniformity early in the growth of in vitro Red banana plants is essential, as gene mutations and chromosome rearrangements during tissue culture can jeopardize both cloning and germplasm conservation. In this situation, molecular markers play a pivotal role in confirming genetic stability.

Identity of the 'true' Micraspis discolor (Fabricius) (Coleoptera, Coccinellidae) with illustrated diagnostic notes on other Micraspis spp. in Indian paddy fields.

Micraspis discolor (Fabricius, 1798) (Coleoptera: Coccinellidae), a widely studied complex of externally similar species, is known to be distributed in all the major rice growing countries of the Oriental region. It consists of disjunct populations that have been treated as a single taxonomic entity, but these are not conspecific and show disparities in their morphology. In this paper, we establish the identity of the true M.

MusaRgeneDB: an online comprehensive database for disease resistance genes in spp.

Banana is one of the major food crops and its production is subject to many pests and diseases. Banana breeding exploits wild relatives and progenitor species for the introgression of resistant genes (R) into cultivated varieties to overcome these hurdles. With advances in sequencing technologies, whole-genome sequences are available for many spp.

Immature stages, host plants and natural enemies of Henosepilachna implicata (Mulsant) (Coleoptera: Coccinellidae) with DNA sequence data and a new synonym and notes on some Indian species of Epilachnini.

Life stages of Henosepilachna implicata (Mulsant), an economically important species of Epilachnini in India, are documented and illustrated. Mitochondrial DNA sequence data is provided for the first time for H. implicata with additional details on its host plants, distribution, and natural enemies.

Evidence of viral genome linked protein of banana bract mosaic virus interaction with translational eukaryotic initiation factor 4E of plantain cv. Nendran based on yeast two hybrid system study.

(BBrMV), belongs to the genus and it is an important viral pathogen of bananas and plantains. The eukaryotic translation initiation factor, eIF4E, and its isoform play key roles during the virus infection in plants, particularly . The present study was undertaken to determine the role of BBrMV-viral protein genome-linked (VPg) in virus infectivity by analyzing the interaction with the eukaryotic translation initiation factor eIF4E through yeast two-hybrid system.

A new species of Protoplotina Miyatake (Coleoptera: Coccinellidae) from Tamil Nadu, India.

Protoplotina ambigua sp. n. (Coccinellidae: Plotinini) from the southern Indian state of Tamil Nadu is described and illustrated.

Identification of novel human neutrophil elastase inhibitors from dietary phytochemicals using and studies.

Human neutrophil elastase (HNE) has been well studied as a therapeutic target for inflammatory diseases for several decades. A variety of small-molecule HNE inhibitors have been well known, and their mode of binding at the active site of the enzyme has been determined, but none of them reached clinical trials except sivelestat. In this study, we intended to identify potent dietary phytochemicals that can target the active site of HNE by employing computational methods and inhibition assay.

Anti-inflammatory effects of troxerutin are mediated through elastase inhibition.

Context: Obesity is a chronic low-grade inflammatory state associated with immune cell infiltration into the adipose tissue (AT). We hypothesize that the anti-obesity and anti-inflammatory effects of troxerutin (TX) are mediated through inhibition of elastase.

Objective: To determine the inhibitory effect of TX on elastase and in tumor necrosis factor alpha (TNFα) induced 3T3-L1 adipocytes and the molecular interaction of TX with human neutrophil elastase (HNE).

Marker Assisted Gene Pyramiding (MAGP) for bacterial blight and blast resistance into mega rice variety "Tellahamsa".

Bacterial blight (BB) and fungal blast diseases are the major biotic constraints that limit rice productivity. To sustain yield improvement in rice, it is necessary to developed yield potential of the rice varieties by incorporation of biotic stress resistance genes. Tellahamsa is a well-adapted popular high yielding rice variety in Telangana state, India.

Indirubin-3'-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain.

Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflammatory state. However, studies demonstrating the pharmacological effects of GSK-3β inhibition and the interlinked molecular mechanisms still remain elusive.

Syringic acid (SA) ‒ A Review of Its Occurrence, Biosynthesis, Pharmacological and Industrial Importance.

The use of phytochemicals in control of human diseases have been considerable public and scientific interest in current days. Syringic acid (SA), a phenolic compound often found in fruits and vegetables and which is synthesized via shikimic acid pathway in plants. It shows a wide range of therapeutic applications in prevention of diabetes, CVDs, cancer, cerebral ischemia; as well as it possess anti-oxidant, antimicrobial, anti-inflammatory, antiendotoxic, neuro and hepatoprotective activities.

Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK.

Scopoletin (SPL), a phenolic coumarin, is reported to regulate glucose metabolism. This study is initiated to substantiate the action of SPL on the regulation of insulin signaling in insulin resistant RIN5f cells and high fat, high fructose diet (HFFD)-fed rat model. Adult male Sprague Dawley rats were fed HFFD for 45 days to induce type 2 diabetes and then treated or untreated with SPL for the next 45 days.

A new insight into identification of in silico analysis of natural compounds targeting GPR120.

G-protein coupled receptor (GPR120) is an omega-3 fatty acid receptor that inhibits macrophage-induced tissue inflammation. Recent studies revealed GPR120 promotes colorectal carcinoma through modulation of VEGF, IL-8, PGE2, and NF-kB expression. However, three-dimensional structure of GPR120 is not yet available in Protein Data Bank (PDB).

Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity.

Endoplasmic reticulum (ER), a dynamic organelle, plays an essential role in organizing the signaling pathways involved in cellular adaptation, resilience, and survival. Impairment in the functions of ER occurs in a variety of nutritive disorders including obesity and type 2 diabetes. Here, we hypothesize that (scopoletin) SPL, a coumarin, has the potential to alleviate ER stress induced in vitro and in vivo models by lipotoxicity.