A well-defined phosphine-free metal-ligand cooperative route for -alkylation of aromatic amines activation of renewable alcohols catalyzed by NNN pincer cobalt(II) complexes.

This study presents the direct -alkylation of aromatic amines using greener primary alcohols as alkyl donors, catalyzed by base metal-derived Co(II) catalysts the borrowing hydrogen (BH) method. Two well-defined phosphine-free NNN-type pincer ligands (L1 and L2) were synthesized and utilized to prepare cobalt(II) catalysts C1 and C2. The catalysts were well characterized by UV-vis, IR, HRMS, and single-crystal X-ray diffraction studies.

Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and Bacopa Monnieri for Accelerated Peripheral Nerve Regeneration.

Peripheral nerve injuries (PNIs) often lead to semi or complete loss of motor, sensory and autonomic functions. Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative.

Illustrator-anatomist-clinician triad based pedagogical model in anatomy education: An auxiliary resource amidst lack of hands-on human dissection.

Adherence to the highest ethical standards is mandatory while handling precious human tissues received through the altruistic act of body donation. In 2019, misconduct at the Body Donation Center in Paris led to its closure. This adversely affected the hands-on human dissection sessions within the anatomy education program at Université Paris-Saclay.

AI-driven Personalized Medicine: Transforming Clinical Practice in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) is marked by significant clinical heterogeneity, posing challenges for accurate diagnosis and personalized treatment strategies. Conventional approaches, such as endoscopy and histology, often fail to adequately and accurately predict medium and long-term outcomes, leading to suboptimal patient management. Artificial intelligence (AI) is emerging as a transformative force enabling standardized, accurate, and timely disease assessment and outcome prediction, including therapeutic response.

Quercetin loaded biogenic squalene nano-lipid carriers for the treatment of dry eye syndrome.

In this study, quercetin-incorporated squalene nanostructured lipid carriers (QS-NLCs) were developed to mitigate the pathological conditions of dry eye disease (DED). The melt emulsification method was used to prepare QS-NLCs. The resulting NLCs have 93.

Ultra-high energy spectral prompt PET.

Objective: Utilizing prompt gammas in preclinical pinhole-collimated PET avoids image degradation due to positron range blurring and photon down scatter, enables multi-isotope PET and can improve counting statistics for low-abundance positron emitters. This was earlier reported for 124I, 89Zr and simultaneous 124I -18F PET using the VECTor scanner (MILabs, The Netherlands), demonstrating sub-mm resolution despite long positron ranges. The aim of the present study is to investigate if such sub-mm PET imaging is also feasible for a large variety of other isotopes including those with extremely high energy prompt gammas (>1 MeV) or with complex emission spectra of prompt gammas.

Molecular probe to visualize the effect of a glycolytic inhibitor on reducing NADH levels in a cellular system.

The reduced form of nicotinamide adenine dinucleotide, commonly known as NADH, is an essential coenzyme existing in living organisms. Due to its involvement in various biological process, fluorescence imaging of intracellular NADH levels in different pathological conditions has emerged as an interesting area of research. We report here the exploration of a fluorescent probe, MQ-CN-BTZ, as a dual-channel NADH imaging agent (green and red channels) for cellular systems.

Advancements in Three-Dimensional Super-Resolution Ultrasound Imaging: A Narrative Review.

The lack of sensibility of traditional ultrasound (US) imaging to the slow blood flow in small vessels resulted in the development of microbubble (MB) contrast agents. These MBs are given intravenously, and US imaging can detect them quite effectively. This noninvasive imaging method, known as contrast-enhanced US (CEUS), now makes it possible to accurately assess tissue perfusion and blood flow.

Benign mid-gap halide vacancy states in 2D-bismuth-based halide perovskite microcrystals for enhanced broadband photodetectors.

Lead halide perovskites are widely recognized for their exceptional defect tolerance, setting the benchmark for high-performance optoelectronic applications. Conversely, low-toxicity perovskite-inspired materials (PIMs) typically exhibit suboptimal optoelectronic performance, primarily due to their intrinsic susceptibility to defects. In this study, we address this limitation by exploring the effects of halide vacancies in PIMs through the synthesis of non-stoichiometric CsBiBrI microcrystals (MCs) with a trigonal crystal structure, incorporating iodine vacancies.

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway.

Soybean-based foods enhance cognitive functions by influencing hippocampal mechanisms. These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes to cognitive decline and that no specific soy-derived peptides are known for their potential to mitigate senescence, we examined the efficacy of a thirteen amino acid soy-derived peptide, Soymetide, on a doxorubicin-induced senescence mice model.

Mechanistic investigation on cellular internalization triggering structure-induced conformational modulation of boron-nitrogen luminogens.

Exploring the effects of electron donor (D) and acceptor (A) functional groups in tuning the condensed state properties has been a challenging yet efficient approach to reveal promising materials for cutting-edge applications. Herein, a series of boron-nitrogen (BN) incorporated organic congeners (NBNMe2, NBOMe, NBF, NBCl, NBBr, NBCN, NBPy) appended with functional groups having various degrees of D/A characteristics were developed and their potential in controlling supramolecular assembly and condensed state luminescence features (>90 nm redshift in ) was explored. Despite the minor structural engineering in BN-based small molecules, they effectively modulated conformational orientation and molecular packing, leading to the directed growth of distinct and highly ordered self-assembly patterns, , nanosheets, nanospheres, nanowires, and nanorods.

Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.

Background: Reliable data about the natural history of lung function decline in alpha-1 antitrypsin (AAT) deficient Pi*MZ heterozygotes is largely missing. We hypothesized that, in adults with a tobacco smoking history, lung function deteriorates faster in Pi*MZ compared to Pi*MM genotype.

Methods: We identified 1856 Pi*MM and 79 Pi*MZ participants with ≥20 pack-years tobacco smoking history from the SPIROMICS cohort by DNA sequencing and followed them over a median of 4.

Fabrication of Folic Acid-Derived Carbon Dot-Conjugated Chitosan Nanospheres as Theragnostic Agents for pH-Responsive Anticancer Drug Delivery.

The favorable success rate in cancer treatment predominantly depends on precise diagnosis with target-specific drug delivery, which can regulate the patient survival outcome rate. Moreover, proper tracking of the system's pH is very much crucial as most of the therapeutic's action and release rate depend on it. Therefore, this work has been intended to fabricate a folic acid-derived carbon dot (FACD) decorated with chitosan (Cs) in order to form nanospheres (FACD-Cs-Ns) for anticancer doxorubicin hydrochloride (Dox.

Exposures from oil and gas development and childhood leukemia risk in Colorado: A population-based case-control study.

Background: Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphocytic leukemia (ALL).

Methods: We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at age 2-9 years starting in 2002 to 2706 controls on birth month/year and Hispanic ethnicity.

Lipoid Proteinosis-An Unusual Cause of Hoarseness of Voice in a Child: Case Report.

Lipoid proteinosis is a rare hereditary multisystemic familial disorder characterised by intracellular deposition of hyaline material (Rao and Koppada in Indian J Dermatol Venereol Leprol, 2015; Shah and Shah in J Oral Maxillofac Pathol 26:236-241, 2022). The hallmark findings are pox like scarred skin lesion, hoarseness of voice and selective brain parenchymal calcification (Rao and Koppada in Indian J Dermatol Venereol Leprol, 2015). We present a case of biopsy proven lipoid proteinosis with typical radiological findings.

Examining the contribution of charge transport layers to boost the performance over 26% in SrPCl absorber-based bifacial perovskite solar cells.

Strontium phosphorus chloride (SrPCl) presents a promising option for photovoltaic (PV) applications due to its distinctive optical, electrical, and structural characteristics. This research uses density functional theory (DFT) to examine its structural stability and optoelectronic properties. The PV performance of SrPCl-based cell designs was examined, utilizing an electron transport layer (ETL) of ZnO and four different hole transport layers (HTLs): CuO, CBTS, MoO, and CuI.

Synergistic Therapeutic Effects of Zn ions and Pimozide in Breast Cancer Cells.

Zinc (Zn) ions play a crucial role in cancer therapy due to their ability to induce reactive oxygen species (ROS) generation, oxidative stress, and ferroptosis. Combining Zn ions with other therapeutic agents can significantly enhance their efficacy through synergistic mechanisms. This study explores the synergistic mechanism of Zn ions form pH-responsive ZIF-8 and repurposed drug Pimozide in tumor microenvironment mimic conditions.

Microbiological Profiles and Resistance Patterns in Pediatrics With Cancer: An 8-Year Study at a Comprehensive Cancer Center in Jordan.

Introduction: Infections impact morbidity and mortality in pediatric cancer patients, yet limited studies have assessed the microbiological profiles and susceptibility patterns of pathogenic bacteria in this population. This study aimed to investigate bacterial profiles and temporal resistance changes in pediatrics with cancer.

Methods: We identified positive cultures between January 2015 and December 2022 for pediatric patients diagnosed with cancer at age < 18 years.

LungGENIE: the lung gene-expression and network imputation engine.

Background: Few cohorts have study populations large enough to conduct molecular analysis of ex vivo lung tissue for genomic analyses. Transcriptome imputation is a non-invasive alternative with many potential applications. We present a novel transcriptome-imputation method called the Lung Gene Expression and Network Imputation Engine (LungGENIE) that uses principal components from blood gene-expression levels in a linear regression model to predict lung tissue-specific gene-expression.

Amphiphilic food polypeptides via moderate enzymatic hydrolysis of chickpea proteins: Bioprocessing, properties, and molecular mechanism.

Plant proteins are a promising source for producing amphiphilic polypeptides with tailored techno-functional properties to be used in various food applications, such as fat replacers. This study investigated the effects of moderate enzymatic hydrolysis on amphiphilic polypeptide generation, by understanding the relationship of bioprocess - protein structure - functionality - amphiphilicity mechanism. Compared to non-specific protease alcalase, the specific protease trypsin catalyzed the production of polypeptides with higher surface hydrophobicity and relatively high molecular weight.

Endostatin and Cystatin C as Predictors of 1 Month Renal Function Change in Patients With Left Ventricular Assist Device Support.

First-month renal function trajectories after left ventricular assist device (LVAD) implantation vary widely. Lack of renal function improvement (RFI) and postoperative acute kidney injury (AKI) are associated with increased mortality. This study evaluates plasma levels of endostatin and cystatin C as predictors of RFI and AKI 1 month post-LVAD implantation.

Modular Approach for Photoinduced Cycloaddition Enabling the Synthesis of Diverse Bioactive Oxazoles.

The synthesis of bioactive oxazoles is often inefficient, and the reported methods remain largely unexplored for complex derivatives. To circumvent this issue, we have utilized a metal-free, photomediated [3 + 2] cycloaddition reaction between diazo compounds and nitriles, leading to a step- and reagent-economical synthesis of bioactive oxazoles. These exciting developments guided us in the efficient synthesis of oxazole-based natural products like annuloline, alkaloids like pimprinethine, labradorin 2, and oxazole-containing pharmaceuticals such as oxaprozin.