Characterization of a Bioactive Chitosan Dressing: A Comprehensive Solution for Different Wound Healing Phases.

Wound management has made significant advances over the past few decades, particularly with the development of advanced dressings that facilitate autolytic debridement, the absorption of wound exudate, and protection from external bacteria. However, finding a single dressing that effectively addresses all four phases of wound healing─hemostasis, inflammation, proliferation, and remodeling─remains a major challenge. Additionally, biofilms in chronic wounds pose a substantial obstacle by shielding microbes from topical antiseptics and antibiotics, thereby delaying the healing process.

Artificial neural network analysis of Jeffrey hybrid nanofluid with gyrotactic microorganisms for optimizing solar thermal collector efficiency.

This article investigates solar energy storage due to the Jeffrey hybrid nanofluid flow containing gyrotactic microorganisms through a porous medium for parabolic trough solar collectors. The mechanism of thermophoresis and Brownian motion for the graphene and silver nanoparticles are also encountered in the suspension of water-based heat transfer fluid. The gyrotactic microorganisms have the ability to move in an upward direction in the nanofluid mixture, which enhances the nanoparticle stability and fluid mixing in the suspension.

Comparison of 1 Week Accelerated Ponseti and Standard Ponseti Technique for Management of Idiopathic Congenital Talipes Equinovarus Deformity in Infants: A Randomized Controlled Trial.

Background: The implementation of the standard Ponseti technique (SPT) in management of idiopathic clubfoot can be challenging due to the need for frequent travelling and long duration to achieve correction. The one week accelerated Ponseti technique (OWAPT) reduces the duration of correction to seven days and has been reported to be effective and safe. However, children still need to travel for change of cast.

Telemedicine in Pediatric Diabetes Care: The Way Forward?

Objective: Data regarding the efficacy and feasibility of telemedicine services in type 1 diabetes (T1D) are sparse in India. This study was planned to assess non-inferiority of glycemic control and diabetes knowledge score after outreach care via telemedicine.

Methods: The study enrolled persons with T1D (age £ 25 years).

Analytical ab initio hessian from a deep learning potential for transition state optimization.

Identifying transition states-saddle points on the potential energy surface connecting reactant and product minima-is central to predicting kinetic barriers and understanding chemical reaction mechanisms. In this work, we train a fully differentiable equivariant neural network potential, NewtonNet, on thousands of organic reactions and derive the analytical Hessians. By reducing the computational cost by several orders of magnitude relative to the density functional theory (DFT) ab initio source, we can afford to use the learned Hessians at every step for the saddle point optimizations.

Exploring the influence of invasive weed biochar on the sorption and dissipation dynamics of imazethapyr in sandy loam soil.

The management of invasive weeds on both arable and non-arable land is a vast challenge. Converting these invasive weeds into biochar and using them to control the fate of herbicides in soil could be an effective strategy within the concept of turning waste into a wealth product. In this study, the fate of imazethapyr (IMZ), a commonly used herbicide in various crops, was investigated by introducing such weeds as biochar, i.

Safety and efficacy of COVID-19 vaccines: A systematic review and meta-analysis of controlled and randomized clinical trials.

Vaccines against coronavirus disease 2019 (COVID-19) have been discovered within a very small duration of time as compared to the traditional way for the development of vaccines, which raised the question about the safety and efficacy of the approved vaccines. The purpose of this study is to look at the effectiveness and safety of vaccine platforms against the incidence of COVID-19. The literature search was performed on PubMed/Medline, Cochrane, and clinical trials.

Interaction and Stability of Nanobubbles and Prenucleation Calcium Clusters during Ultrasonic Treatment of Hard Water.

To investigate the stability of nanobubbles in natural hard water, a series of eight samples ranging in hardness from 0 to 332 mg/L CaCO were sonicated for periods of 5-45 min with an ultrasonic horn. Conductivity, temperature, ζ-potential, composition, and pH of the water were analyzed, together with the crystal structure of any calcium carbonate precipitate. Quasi-stable populations of bulk nanobubbles in Millipore and soft water are characterized by a ζ-potential of -35 to -20 mV, decaying over 60 h or more.

Transformer-based tool recommendation system in Galaxy.

Background: Galaxy is a web-based open-source platform for scientific analyses. Researchers use thousands of high-quality tools and workflows for their respective analyses in Galaxy. Tool recommender system predicts a collection of tools that can be used to extend an analysis.

Synthesis of Hidden Subgroup Quantum Algorithms and Quantum Chemical Dynamics.

We describe a general formalism for quantum dynamics and show how this formalism subsumes several quantum algorithms, including the Deutsch, Deutsch-Jozsa, Bernstein-Vazirani, Simon, and Shor algorithms as well as the conventional approach to quantum dynamics based on tensor networks. The common framework exposes similarities among quantum algorithms and natural quantum phenomena: we illustrate this connection by showing how the correlated behavior of protons in water wire systems that are common in many biological and materials systems parallels the structure of Shor's algorithm.

Effect of glucocorticoids on the development of COVID-19-associated pulmonary aspergillosis: A meta-analysis of 21 studies and 5174 patients.

COVID-19-associated pulmonary aspergillosis (CAPA) remains a high mortality mycotic infection throughout the pandemic, and glucocorticoids (GC) may be its root cause. Our aim was to evaluate the effect of systemic GC treatment on the development of CAPA. We systematically searched the PubMed, Google Scholar, Scopus and Embase databases to collect eligible studies published until 31 December 2022.

Cost-Efficacy Analysis of Use of Frozen Section Histology for Margin Assessment During Breast Conservation Surgery in Breast Cancer Patients.

Background: Margin assessment is an essential component of breast conservation surgery (BCS). Re-excision of infiltrated margin(s) detected on paraffin section histology (PSH) needs reoperation, adding time, inconvenience and cost. Intra-operative assessment of margins using frozen section histology (IFSH) can potentially obviate need for re-operation, thus facilitating one-step oncologically complete BCS.

Use of appropriate statistical tools in biomedical research: Current trend & status.

Background & Objectives: Due to lack of appropriate statistical knowledge, published research articles contain various errors related to the design, analysis and interpretation of results in the area of biomedical research. If research contains statistical error, however, costly, it may be of no use and the purpose of the investigation gets defeated. Many biomedical research articles published in different peer reviewed journals may retain several statistical errors and flaws in them.

A Randomized Controlled Study of Robot-Assisted versus 3D Laparoscopic Radical Prostatectomy in Patients with Carcinoma Prostate.

Materials And Methods: A prospective randomized comparative study was performed from 1st January 2020 to 30th June 2021. All patients included were diagnosed with localized/locally advanced ca prostate. 60 patients fulfilling the inclusion and exclusion criteria were randomized into 2 groups.

Effect of soil amendments on the sorption behavior of atrazine in sandy loam soil.

The sorption behavior of pesticides applied during cultivation of crops is affected by amendments such as farm yard manure (FYM) and vermicompost (VC) during land preparation. Among pesticides, atrazine, a widely used herbicide in many crops, was analyzed for its kinetics and sorption behavior through the addition of FYM and VC in sandy loam soil. The pseudo-second-order (PSO) model best fit the kinetics results in the recommended dose of FYM and VC mixed soil.

Grid and Image Intensifier Improve Arthroscopic ACL Tunnel Position and Patient-Reported Outcomes.

Purpose: To evaluate the accuracy in the femoral and tibial tunnel placement after the use of fluoroscopy along with an indigenously designed grid method to assist in arthroscopic anterior cruciate ligament reconstruction as compared with the tunnel placement without using them and to validate the findings with computed tomography scan performed postoperatively along with assessing the functional outcome at a minimum of 3 years of follow-up.

Methods: This was a prospective study conducted on patients who underwent primary anterior cruciate ligament reconstruction. Patients were included and segregated into a nonfluoroscopy (group B) and a fluoroscopy group (group A), and both had postoperative computed tomography scans so that femoral and tibial tunnel position could be evaluated.

An accessible infrastructure for artificial intelligence using a Docker-based JupyterLab in Galaxy.

Background: Artificial intelligence (AI) programs that train on large datasets require powerful compute infrastructure consisting of several CPU cores and GPUs. JupyterLab provides an excellent framework for developing AI programs, but it needs to be hosted on such an infrastructure to enable faster training of AI programs using parallel computing.

Findings: An open-source, docker-based, and GPU-enabled JupyterLab infrastructure is developed that runs on the public compute infrastructure of Galaxy Europe consisting of thousands of CPU cores, many GPUs, and several petabytes of storage to rapidly prototype and develop end-to-end AI projects.

Migrated K-wire in the urinary bladder not causing symptoms: A rare case report.

Introduction And Importance: Kirschner wires (K-wires) are commonly used implants in the treatment of bony fracture. The migration of K-wire has been reported in the literature, but such migration into the urinary bladder is extremely rare.

Presentation Of Case: We report a case of an asymptomatic patient with a migrating K-wire in the urinary bladder, who came to our follow-up clinic after treatment of a hip fracture.

Arterial cannulation in adult critical care patients: A comparative study between ultrasound guidance and palpation technique.

Objective: To compare first attempt success rate for ultrasound-guided (USG) versus direct palpation (DP) for radial, femoral, and dorsalis pedis artery cannulations in adult intensive care unit (ICU) patients.

Design: Prospective randomized clinical trial.

Setting: Mixed adult ICU of a University Hospital.

The Impact of COVID-19 on the Clinical Practices, Working Environment, and Social Life of Intensivists in Non-COVID ICU.

Purpose: Enlightening the changes in the usual clinical practices, working environment, and social life of Intensivists working in noncoronavirus disease intensive care units (non-COVID ICU) during the COVID pandemic.

Materials And Methods: Observational cross-sectional study for Indian intensivists working in non-COVID ICUs conducted between July and September 2021. A 16-question online survey consisting of the work and social profile of the participating intensivists, changes in the usual clinical practices, working environment, and impact on their social life was administered.

Adenoviral Vector-Based Vaccine Platform for COVID-19: Current Status.

The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the 21st century, claiming millions of lives and putting a huge burden on the global economy. The potential developments in vaccine technologies following the determination of the genetic sequence of SARS-CoV-2 and the increasing global efforts to bring potential vaccines and therapeutics into the market for emergency use have provided a small bright spot to this tragic event. Several intriguing vaccine candidates have been developed using recombinant technology, genetic engineering, and other vaccine development technologies.

Entropy Generation and Thermal Radiation Analysis of EMHD Jeffrey Nanofluid Flow: Applications in Solar Energy.

This article examines the effects of entropy generation, heat transmission, and mass transfer on the flow of Jeffrey fluid under the influence of solar radiation in the presence of copper nanoparticles and gyrotactic microorganisms, with polyvinyl alcohol-water serving as the base fluid. The impact of source terms such as Joule heating, viscous dissipation, and the exponential heat source is analyzed via a nonlinear elongating surface of nonuniform thickness. The development of an efficient numerical model describing the flow and thermal characteristics of a parabolic trough solar collector (PTSC) installed on a solar plate is underway as the use of solar plates in various devices continues to increase.