Publications by authors named "Anum S Minhas"
Article Synopsis
- Asian individuals are at a higher risk for gestational diabetes in the U.S., with a notable prevalence rate of 12.3% among Asian pregnancies compared to 6.5% overall.
- Data indicates that prepregnancy hypertension increases this risk significantly, with 29.3% of hypertensive Asian subjects affected.
- There are considerable differences in gestational diabetes risk across various Asian subgroups, emphasizing the necessity for personalized screening and interventions based on specific ancestry and maternal nativity.
Article Synopsis
- HIV-associated cardiovascular disease (CVD) is becoming more common, but the reasons for this increased risk in people living with HIV (PWH) are not well understood, particularly regarding lipoprotein(a) [Lp(a)].
- A study involving 65 PWH and 52 controls found that Lp(a) levels were significantly higher in PWH, and they showed lower coronary endothelial function (CEF) as measured by cardiac imaging.
- The study concluded that elevated Lp(a) in PWH is linked to impaired CEF, suggesting that Lp(a) might contribute to the increased cardiovascular risk in this population.
Article Synopsis
- Prepregnancy diabetes and obesity are significant risk factors for hypertensive disorders of pregnancy (HDPs), with 7% of birthing individuals in a study experiencing HDP.
- Among different racial and ethnic groups, HDP was most prevalent in American Indian and Alaska Native individuals, while diabetes and obesity showed the strongest associations with HDPs in Native Hawaiian and Other Pacific Islander and Asian individuals, respectively.
- The study found that diabetes and obesity account for notable population attributable fractions of HDPs, emphasizing the need for targeted interventions, especially among vulnerable populations such as Native Hawaiian and Other Pacific Islander individuals.
Background: Maternal mortality in the United States remains high, with cardiovascular (CV) complications being a leading cause.
Objectives: The purpose of this paper was to develop the PARCCS (Prediction of Acute Risk for Cardiovascular Complications in the Peripartum Period Score) for acute CV complications during delivery.
Methods: Data from the National Inpatient Sample (2016-2020) and International Classification of Diseases, Tenth Revision codes to identify delivery admissions were used.
Background: Gestational diabetes mellitus (GDM) is associated with increased long-term risk of cardiovascular disease but the cardiovascular structural and functional changes that contribute to risk are not well understood.
Objectives: The purpose of this study was to determine whether GDM is associated with adverse cardiac remodeling and endothelial dysfunction a decade after delivery, independent of type 2 diabetes.
Methods: Women with deliveries between 2008 and 2009 were initially selected from a prospective clinical cohort.
Article Synopsis
- - The study analyzes preeclampsia outcomes in different US regions, focusing on complications and management of the condition based on data from The Preeclampsia Registry which includes mostly White women (92%) across various regions (Northeast, Midwest, South, and West).
- - Results reveal that women in the South and Midwest had the highest maximum systolic blood pressure during pregnancy, with Southern women receiving more pre-pregnancy antihypertensives and antenatal steroids, and delivering earlier than their counterparts in other regions.
- - Regional differences also showed that women in the South experienced higher rates of complications like elevated liver enzymes, and more severe conditions like renal complications and hemolysis were noted in women from the
Background And Aims: Persons with rheumatoid arthritis (RA) have an increased risk of obstetric-associated complications, as well as long-term cardiovascular (CV) risk. Hence, the aim was to evaluate the association of RA with acute CV complications during delivery admissions.
Methods: Data from the National Inpatient Sample (2004-2019) were queried utilizing ICD-9 or ICD-10 codes to identify delivery hospitalizations and a diagnosis of RA.
A 37-year-old woman with mechanical tricuspid valve thrombosis presented for preconception consultation. Multimodality imaging confirmed a malfunctioning bileaflet mechanical tricuspid valve with both leaflets fixed and open. This case highlights the key discussions held by the multidisciplinary pregnancy heart team.
View Article and Find Full Text PDFA 27-year-old pregnant woman at 24 weeks of gestation was admitted with cardiogenic shock due to mechanical mitral valve thrombosis. Following discussion with the heart team, thrombolysis was achieved with tissue plasminogen activator therapy followed by heparin infusion. Ultimately, the patient required mitral valve replacement for persistently elevated gradients.
View Article and Find Full Text PDFAssisted reproductive technology: what are the cardiovascular risks for women?
Expert Rev Cardiovasc Ther
November 2023
Article Synopsis
- Infertility affects 15% of women of reproductive age in the U.S., with rising use of assisted reproductive technology (ART) and increasing awareness of its link to cardiovascular disease (CVD) risk.
- Women undergoing ART often have pre-existing CVD risk factors like obesity and hypertension, face higher chances of adverse pregnancy outcomes, and increased cardiometabolic demands during pregnancy.
- More research is needed to understand the long-term CVD risks associated with ART, emphasizing the importance of screening and management of CVD risk factors before and during pregnancy to improve health outcomes.
Article Synopsis
- - Cardiovascular disease (CVD) is the top cause of death among women worldwide, influenced by both traditional risk factors (like diabetes and smoking) and unique female-specific factors (like age of menarche and conditions such as polycystic ovary syndrome).
- - Recognizing these female-specific risk factors is important for a thorough cardiovascular risk assessment, helping to identify women who might benefit from more intensive preventive measures such as lifestyle changes or medications like statins.
- - The review discusses the differences between men and women regarding CVD risk factors, including the use of coronary artery calcium scores and certain biomarkers to improve risk assessment and inform prevention strategies.
Background: Female-specific factors of grand multiparity (≥5 births) and early menopause age are associated with an increased risk of cardiovascular disease (CVD). However, mechanisms are incompletely understood. Carotid plaque is a marker of subclinical atherosclerosis and associated with increased CVD risk.
View Article and Find Full Text PDFMaternal psychosocial stress may be a risk factor for poor cardiovascular health (CVH) during pregnancy. We aimed to identify classes of psychosocial stressors in pregnant women and to evaluate their cross-sectional association with CVH. We performed a secondary analysis of women from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) cohort (2010 to 2013).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) change during pregnancy across different trimesters.
- Researchers analyzed data from 2,134 women, including 546 who were pregnant, to compare NT-proBNP levels by pregnancy status and trimester.
- Results show that NT-proBNP is significantly higher in the first trimester compared to the third trimester and nonpregnant women, indicating that NT-proBNP levels vary considerably during pregnancy and should be factored into lab test interpretations.
Aim: We sought to evaluate the performance of glycated albumin (GA) as a measure of hyperglycemia in pregnant women.
Methods: We used data from 555 pregnant women aged 20-40 years who participated in NHANES 1999-2004 and did not report a pre-pregnancy diagnosis of diabetes. We used Pearson's correlations and evaluated the area under the curve (AUC) for GA to detect elevated concentrations of random glucose, HbA1c, or fasting glucose (subset).
Background: Cardiac arrhythmias are associated with increased maternal morbidity. There are limited data on trends of arrhythmias among women hospitalized for delivery.
Materials And Methods: We used the National Inpatient Sample (NIS) database to identify delivery hospitalizations for individuals aged 18-49 years between 2009 to 2019 and utilized coding data from the 9th and 10th editions of the to identify supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter, ventricular tachycardia (VT), and ventricular fibrillation (VF).
Background Impaired coronary endothelial function (CEF) predicts cardiovascular events and occurs in people living with HIV (PLWH). Women compared with men living with HIV have worse cardiovascular outcomes, but prior CEF studies included few women. The authors aimed to compare CEF in women with HIV versus without HIV, investigate sex differences in CEF and PCSK9 (proprotein convertase subtilisin/kexin type 9) (a proinflammatory biomarker), and evaluate whether increased serum levels of PCSK9 are associated with CEF in PLWH.
View Article and Find Full Text PDFArticle Synopsis
- Gestational diabetes (GD) is linked to long-term cardiovascular issues and the study focused on its impact on acute cardiovascular complications during delivery.
- Data from over 63 million hospitalizations between 2004 and 2019 showed that individuals with GD had higher rates of obesity, hypertension, and several cardiovascular complications, even when controlling for factors like age and insurance.
- The study found that delivery hospitalizations for those with GD were longer and more expensive, highlighting the need for strategies to improve maternal health and potentially reduce GD rates globally.
Article Synopsis
- * Data from over 45 million delivery cases from 2008 to 2019 show that women using ART were generally older, more likely to have health issues like hypertension and gestational diabetes, and had longer and more expensive hospital stays.
- * While ART was linked to increased risks of conditions like pre-eclampsia, heart failure, and various types of strokes, it did not show a significant association with peripartum cardiomyopathy or acute coronary syndrome.