Effects of Minocycline on Urine Albumin, Interleukin-6, and Osteoprotegerin in Patients with Diabetic Nephropathy: A Randomized Controlled Pilot Trial.

Background: We tested minocycline as an anti-proteinuric adjunct to renin-angiotensin-aldosterone system inhibitors (RAASi) in diabetic nephropathy (DN) and measured urinary biomarkers to evaluate minocycline's biological effects.

Design: Prospective, single center, randomized, placebo-controlled, intention-to-treat pilot trial. Inclusion.

Is there a role for ketoacid supplements in the management of CKD?

Ketoacid (KA) analogues of essential amino acids (EAAs) provide several potential advantages for people with advanced chronic kidney disease (CKD). Because KAs lack the amino group bound to the α carbon of an amino acid, they can be converted to their respective amino acids without providing additional nitrogen. It has been well established that a diet with 0.

Searching for new care models for chronic kidney disease.

Chronic kidney disease is associated with increased death risk. The estimated size of this high-risk population is too large for effective care to be delivered by nephrologists alone and will require models of care delivery that include partnerships with primary-care physicians and incorporate physician extenders. Studies show that some of these care models provide outcomes similar to those seen with nephrologists as sole providers; whether they are cost-effective or improve satisfaction with care remains to be demonstrated.