Publications by authors named "Anuja Chakraborty"
Article Synopsis
- 5-Fluorouracil (5-FU) is a key chemotherapy drug for treating hepatocellular carcinoma, but its effectiveness decreases due to cancer cells developing resistance, mainly through a process called autophagy.
- This study explores how manipulating nutrient levels, particularly through starvation, can enhance the efficacy of 5-FU by increasing cancer cell death while minimizing harm to normal cells.
- Results indicate that combining 5-FU with nutritional deprivation boosts cell death via mitochondrial damage and increased reactive oxygen species (ROS), which could pave the way for new treatment strategies against liver cancer.
The therapeutic value of mesenchymal stem cells (MSCs) for the treatment of infectious diseases and the repair of disease-induced tissue damage has been explored extensively. MSCs inhibit inflammation, reduce pathogen load and tissue damage encountered during infectious diseases through the secretion of antimicrobial factors for pathogen clearance and they phagocytose certain bacteria themselves. MSCs dampen tissue damage during infection by downregulating the levels of pro-inflammatory cytokines, and inhibiting the excessive recruitment of neutrophils and proliferation of T cells at the site of injury.
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