High-grade Serous Carcinoma Occurring in a Serous Cystadenoma on the Background of a Serous Tubal Intraepithelial Carcinoma (STIC)-like Lesion: A Case Report With Literature Review.

At present, the prevailing concept is that high-grade serous carcinoma (HGSC) arises from the fallopian tubes (FTs). We report an HGSC case occurring in a serous ovarian cyst against the background of a serous tubal intraepithelial carcinoma (STIC)-like lesion. We also provide a literature review that contains references to clinical cases of the occurrence of STIC-like lesions in the ovary and phylogenetic studies that do not always reveal obvious bonds between early dysplastic serous lesions and HGSC.

α1-Adrenergic receptor regulates papillary muscle and aortic segment contractile function via modulation of store-operated Ca entry in long-tailed ground squirrels Urocitellus undulatus.

The effect of phenylephrine (PE) on right ventricle papillary muscle (PM) and aortic segment (AS) contractile activity was studied in long-tailed ground squirrels Urocitellus undulatus during summer activity, torpor and interbout active (IBA) periods in comparison to rat. We found that PE (10 μM) exerts positive inotropic effect on ground squirrel PM that was blocked by α1-AR inhibitor-prazosin. PE differently affected frequency dependence of PM contraction in ground squirrels and rats.

[Five-year outcomes of aorto-femoral vascular reconstructions in patients with multifocal atherosclerosis].

Aim: To analyze long-term results of surgical treatment of atherosclerotic occlusive-stenotic lesion of aorto-femoral segment within the single-center prospective register.

Material And Methods: The study included 275 patients who underwent aorto-femoral reconstructive interventions for the period 2011-2014. Inclusion criterion was indications for aorto-femoral surgery due to severe atherosclerotic lesions of the infrarenal aorta and/or ilio-femoral arteries.

[Simultaneous operation in a patient with stenosis of the extracranial portion and an intracranial aneurysm of the internal carotid artery].

Presented herein is a clinical case report concerning surgical treatment of a patient with a rare combination of two pathologies, i. e., a haemodynamically significant stenosis of the extracranial portion and a sacciform aneurysm of the communicative portion of the right internal carotid artery on the background of multifocal atherosclerosis.

Store-operated Ca2+ entry supports contractile function in hearts of hibernators.

Hibernators have a distinctive ability to adapt to seasonal changes of body temperature in a range between 37°C and near freezing, exhibiting, among other features, a unique reversibility of cardiac contractility. The adaptation of myocardial contractility in hibernation state relies on alterations of excitation contraction coupling, which becomes less-dependent from extracellular Ca2+ entry and is predominantly controlled by Ca2+ release from sarcoplasmic reticulum, replenished by the Ca2+-ATPase (SERCA). We found that the specific SERCA inhibitor cyclopiazonic acid (CPA), in contrast to its effect in papillary muscles (PM) from rat hearts, did not reduce but rather potentiated contractility of PM from hibernating ground squirrels (GS).

[Optimization of educational activity of departments of educational creativity in the Extension Course Institute for Medical Practitioners MUNKTs n. a. P.V.Mandryka].

Educational creativity is the key component of educational activity. The article is devoted to logical structure of educational creativity, difficulties and problems of formation and development of educational creativity in lecturers participating in educative process with participants of the Extension Course Institute for Medical Practitioners MUNKTs n. a.

[Possible reasons for the variability of the inotropic insulin effect in papillary muscles of ground squirrel myocardium].

The effects of insulin (0.1-50 nM) on isometric twitch force (0.1 to 1.

[Comparative analysis of arterial bioprostheses with various antithrombotic modification].

The present study was aimed at comparing the results of remote patency ol arterial bioprosthcses «KemAngioprosthesis» in infrainguinal position with various antithromhotic modifi cation. We analyzed the outcomes in a total of 133 patients who were subdivided into two groups: Group I (n=91) underwent implantation of hioprostheses with antithrombotic modifi calion by non-fractionated heparin. and Group II (n=42) received prostheses treated with low-molecular-weight heparin «Clexane».

The seasonal peculiarities of force-frequency relationships in active ground squirrel Spermophilus undulatus ventricle.

The plasticity of calcium homeostasis is of crucial importance for the unique ability of the hibernators' heart to function under conditions of body temperature changing from 37 degrees C to near freezing point. However, the precise mechanism of calcium homeostasis regulation in these animals is largely unknown. Force-frequency relationship, as an indicator of participation of various sources of calcium (external and intracellular) in the activation of contraction, and post-rest potentiation as an index of the capacity of sarcoplasmic reticulum (intracellular calcium source) to store and release Ca(2+), were studied to analyse the role of different calcium-transporting systems in seasonal and temperature-induced changes in isometric twitch force of ground squirrel papillary muscles.

[Twelve-year experience of bioprosthesis implantation into infrainguinal arteries].

The study presents the results of 315 infrainguinal artery reconstructions with bioprostheses from bovine internal mammary artery treated with 5% solution of diepoxide (trade name "KemAngioprosthesis"). Primary patency of KemAngioprostheses was 37.5% (n=239) in above-knee and 7.

[Characteristics of force-frequency relations in the myocardium of the squirrel Citellus undulatus].

The force-frequency relationship (FFR) in papillary muscles of the heart of active ground squirrel in different seasons was studied. For comparison, similar preparations from rat and rabbit were used. It was shown that the FFR of papillary muscles of active ground squirrel undergo significant seasonal changes.