Publications by authors named "Antti Lempinen"
Article Synopsis
- - T-type calcium (Ca3) channels play a crucial role in heart function, particularly in heart conditions like hypertrophy and failure, but there's a lack of clinical inhibitors for them.
- - The study focused on purpurealidin analogs from marine sponges to find novel inhibitors and identified purpurealidin I as having a significant inhibitory effect on the rat Ca3.1 channel.
- - Four potent analogs were found to inhibit the Ca3.1 channel by blocking its ion flow, without altering the activation curve, and also showed activity on hERG channels, paving the way for new drug designs targeting T-type Ca channels.
Marine-originated spirocyclic bromotyrosines are considered as promising scaffolds for new anticancer drugs. In a continuation of our research to develop potent and more selective anticancer compounds, we synthesized a library of 32 spirocyclic clavatadine analogs by replacing the agmatine, i.e.
View Article and Find Full Text PDFProtein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydrophobic isophthalic acid derivatives that modify PKC functions by binding to the C1 domain of the enzyme. In the present study, we aimed to improve the drug-like properties of the isophthalic acid derivatives by increasing their solubility and enhancing the binding affinity.
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