Publications by authors named "Antti Jokiniitty"
Article Synopsis
- The study investigates the prevalence of familial hypercholesterolemia (FH) in Finnish patients with premature coronary artery disease (CAD) and high LDL cholesterol levels.
- Out of 28,295 angiography patients, 162 were identified with premature CAD, and 80 underwent genetic testing, revealing a 73% likelihood of FH among them.
- The genetically verified FH prevalence was found to be 1:16 in those with premature CAD, significantly higher than the general population rate of 1:600.
Background And Aims: To validate an automated screening tool for patients with premature coronary artery disease (CAD) and high total cholesterol or LDL-C levels and assess if it would provide clinicians with additional support in identifying patients with Familial Hypercholesterolemia (FH).
Methods: An IT-based automated screening tool based on coronary angiography data recorded in the KARDIO registry and laboratory values was validated among patients undergone coronary angiography in the Heart Hospital at Tampere University Hospital between 2007 and 2017 fulfilling the criteria of premature CAD (men <55 years and women <60 years) and history of high total cholesterol (>8 mmol/l) or LDL-cholesterol (>5 mmol/l) levels. Electronic health records were retrospectively analyzed to determine if these patients had been diagnosed with FH based on clinical features and whether genetic testing had been conducted.