Publications by authors named "Antrix N Jain"
Mol Cell Proteomics
April 2017
Article Synopsis
- Neurofibromin (NF1) is a crucial tumor suppressor that regulates RAS activity and is frequently mutated in cancer cases, but a comprehensive understanding of its interaction network has been lacking.
- Using CRISPR/Cas9 technology and mass spectrometry, researchers identified 49 candidate proteins interacting with NF1, including RAS, and revealed that NF1 inhibits mTOR signaling via LAMTOR1.
- NF1-deficient cells showed increased reliance on hyperactivated mTOR for growth and survival, suggesting potential therapeutic strategies targeting these pathways in tumors lacking functional NF1.
