Publications by authors named "Antony Sutherland"
Neurol Clin Pract
February 2025
Article Synopsis
- The study examines the types of diagnoses given to patients referred for frontal network impairments at a cognitive neurology clinic in Melbourne, specifically looking into cases suspected of frontotemporal dementia (FTD).
- Out of 161 patients analyzed over a decade, the most common final diagnosis was an FTD syndrome, with behavioral variant FTD being the most frequent sub-type.
- Other diagnoses included primary psychiatric disorders, vascular cognitive impairment, and Alzheimer's disease, with behavioral variant FTD patients showing higher rates of medical comorbidities.
Article Synopsis
- The study identifies BBC3 (PUMA) as a crucial protein that regulates germ cell death during ovarian development, impacting the number of primordial follicles formed.
- Disruption of the Bbc3 gene led to a significant increase in germ cell counts in female mice, resulting in a nearly doubled number of primordial follicles by postnatal day 10.
- BBC3 is essential for controlling germ cell death early in development but does not influence germ cell proliferation or the subsequent loss of germ cells during later stages.
