Publications by authors named "Antonn Cheeseman"
Article Synopsis
- Pro-inflammatory immune responses are suppressed during blood-stage malaria, but the specific molecular mechanisms behind this are not fully clear.
- This study reveals that the co-inhibitory receptors TIGIT and PD-1 are increased in certain T cells during a non-lethal malaria infection.
- Blocking both TIGIT and PD-L1 together leads to better parasite control and heightened production of key immune signaling molecules, suggesting these receptors play a crucial role in managing the body's immune response during malaria infection.
Experimental cerebral malaria (ECM) is a severe complication of Plasmodium berghei ANKA (PbA) infection in mice, characterized by CD8 T-cell accumulation within the brain. Whilst the dynamics of CD8 T-cell activation and migration during extant primary PbA infection have been extensively researched, the fate of the parasite-specific CD8 T cells upon resolution of ECM is not understood. In this study, we show that memory OT-I cells persist systemically within the spleen, lung and brain following recovery from ECM after primary PbA-OVA infection.
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