Publications by authors named "Antonius Eze"
Article Synopsis
- The Aurora family of kinases is crucial for chromosome division and cell separation, relying on specific protein scaffolds for regulation, but the malaria-causing Plasmodium spp. have unique aurora-related kinases (ARK1-3) that operate without many typical scaffolds.
- The study focuses on ARK2 in Plasmodium berghei's sexual reproduction, using advanced imaging and analysis techniques to demonstrate its role at spindle microtubules during cell division.
- Key findings show that ARK2 and its interactors, like EB1, are important for non-traditional chromosome segregation, highlighting how the malaria parasite adapts its molecular mechanisms for survival and reproduction.
Mechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during cell division through precise spatiotemporal regulation of their catalytic activities by distinct scaffolds. Plasmodium spp.
View Article and Find Full Text PDFMechanisms of cell division are remarkably diverse, suggesting the underlying molecular networks among eukaryotes differ extensively. The Aurora family of kinases orchestrates the process of chromosome segregation and cytokinesis during cell division through precise spatiotemporal regulation of their catalytic activities by distinct scaffolds. spp.
View Article and Find Full Text PDF