A novel microfluidic tool for the evaluation of local drug delivery systems in simulated conditions.

A 3D-printed microfluidic tool for assessing local drug delivery systems (LDD) in simulated conditions was developed and evaluated. The device was designed considering the oral environment and dental applications, and it was fabricated with a high-precision resin 3D printer. Chitosan scaffolds loaded with different concentrations of doxycycline were used for evaluating our device.

Physiologically engineered porous titanium/brushite scaffolds for critical-size bone defects: A design and manufacturing study.

Repairing critical-size bone defects still represents a critical clinical challenge in the field of trauma surgery. This study focuses on a physiological design and manufacturing of porous composite scaffold (titanium Ti with 10 % mole iron doped brushite DCPD-Fe) which can mimic the biomechanical properties of natural cortical bone, specifically for the purpose of repairing critical-size defects. To achieve this, the principle of design of experiments (DOE) was applied for investigating the impact of sintering temperature, mineral ratio, and volume fraction of porosity on the mechanical properties of the fabricated scaffolds.

Synthesis and Study of Fully Biodegradable Composites Based on Poly(butylene succinate) and Biochar.

Biodegradable polymers offer a promising alternative to the global plastic problems and especially in the last decade, to the microplastics problems. For the first time, samples of poly(butylene succinate) (PBSu) biocomposites containing 1, 2.5, and 5 wt% biochar (BC) were prepared by in situ polymerization via the two-stage melt polycondensation procedure.

Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications.

Mesoporous silica-based nanoparticles (MSNs) are considered promising drug carriers because of their ordered pore structure, which permits high drug loading and release capacity. The dissolution of Si and Ca from MSNs can trigger osteogenic differentiation of stem cells towards extracellular matrix calcification, while Mg and Sr constitute key elements of bone biology and metabolism. The aim of this study was the synthesis and characterization of sol-gel-derived MSNs co-doped with Ca, Mg and Sr.

Mechanical and thermal properties of PMMA resin composites for interim fixed prostheses reinforced with calcium β-pyrophosphate.

Interim restorations are essential in fixed prosthodontics as they provide temporary protection of teeth before the insertion of the permanent restoration. Poly(methyl methacrylate) (PMMA) is widely used in the fabrication of interim-fixed restorations as it is a biocompatible material with a lot of convenient properties. However, it exhibits low impact and tensile strength and therefore it is necessary to be reinforced.

Analysis of the osteogenic and mechanical characteristics of iron (Fe/Fe)-doped β‑calcium pyrophosphate.

The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO·2HO) has been investigated for osteogenic potential and mechanical properties.