Background: To quantify the levels of tissue inhibitor of metalloproteinase 4 (TIMP4) and its ratios with free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation syndrome (PXS) and pseudoexfoliative glaucoma (PXG) and to evaluate a possible imbalance between MMPs and TIMPs in these samples.
Methods: Free MMP2, MMP3, MMP9, TIMP1, TIMP2, TIMP4 concentrations and active levels of MMP2 and MMP3 were determined with immunoassay ELISA and activity assay kits in 168 aqueous samples.
Results: TIMP4 was elevated in glaucoma patients(POAG: 0.
Background: To evaluate and compare the recorded IOP values of the Pascal dynamic contour tonometer (PDCT) and the Goldmann applanation tonometer (GAT) after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
Methods: Three groups of 84, 182 and 43 patients each were treated by PRK for myopia, LASIK for myopia and LASIK for hyperopia respectively. Intraocular pressure (IOP) measurements were performed in all eyes 1 day before and 1, 3, 6 and 12 months after treatment with PDCT and GAT.
Graefes Arch Clin Exp Ophthalmol
May 2010
Background: To evaluate the impact of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK), on retinal nerve fiber layer (RNFL) measurements, by means of scanning laser polarimetry (SLP) GDx VCC (with variable corneal compensation).
Methods: Two groups of 119 myopic patients each were treated by PRK and LASIK respectively; one eye of each patient was randomly selected for the study. RNFL measurements (around the entire calculation circle) was performed in all eyes 1 day before and 1, 3, 6 and 12 months after treatment by using SLP GDx VCC.