Publications by authors named "Antonio Spagnolo-Allende"
Background And Purpose: Brain arterial luminal diameters are reliably measured with automated imaging software. Nonautomated imaging software alternatives such as a Picture Archiving Communication System are more common bedside tools used for manual measurement. This study is aimed at validating manual measurements against automated methods.
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- Intracranial atherosclerotic disease (ICAD) is a leading cause of stroke, particularly affecting East Asian and non-White populations more than those of European descent.
- ICAD not only raises the risk of stroke but also contributes to dementia and cognitive decline, with a notably high recurrence rate of over 20% for those with severe stenosis (≥70%).
- Diagnosis primarily involves lumen-based imaging techniques, although newer methods like high-resolution vessel wall MRI may improve the identification of ICAD compared to other artery conditions.
Article Synopsis
- The study investigates the link between red blood cell (RBC) concentrations, measured as hematocrit, and lacunar infarcts—small brain lesions related to ischemic stroke—using two groups: stroke-free adults and acute stroke patients.
- Results showed that in stroke-free older adults, there is a U-shaped relationship, meaning both low and high hematocrit levels are associated with chronic covert lacunar infarcts.
- In acute stroke patients, the study found a direct correlation where higher hematocrit levels were linked to an increased occurrence of acute lacunar strokes, suggesting that RBC concentrations might play a significant role in both chronic and acute brain injury.
Background And Purpose: Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations.
View Article and Find Full Text PDFBackground: Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BADs is unknown.
Methods And Results: The authors studied 4150 participants from 6 geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries).
Article Synopsis
- The study aimed to explore how intracranial arterial calcification (IAC) relates to intracranial large artery stenosis (ILAS) and the likelihood of experiencing vascular events and mortality.
- Researchers used data from two different cohorts, one from a stroke registry and another from a community study, analyzing CT scans and MRI/MRA results to assess IAC and its impact on health outcomes.
- Findings revealed that IAC is significantly linked to both symptomatic and asymptomatic forms of ILAS and associated with increased mortality, though its connection to stroke risk was uncertain.
Background: Brain arterial diameters are novel imaging biomarkers of cerebrovascular disease, cognitive decline and dementia. Traditional vascular risk factors have been associated with brain arterial diameters but whether there may be genetic determinants of brain arterial diameters is unknown.
Results: We studied 4150 participants from six geographically diverse population-based cohorts (40% European, 14% African, 22% Hispanic, 24% Asian ancestries).
Background: Many studies have reported reduced brain white matter fractional anisotropy (FA) and increased mean diffusivity (MD) on diffusion tensor imaging (DTI) of people with HIV (PWH). Few, however, have linked individual blood inflammatory markers with white matter tract-specific FA and MD.
Methods: PWH 50 years old or older from New York, NY, USA, were invited to a cross-sectional study.
As the life expectancy of people living with HIV (PLWH) on combination antiretroviral therapy (cART) increases, so does morbidity from cerebrovascular disease and neurocognitive disorders. Brain arterial remodeling stands out as a novel investigational target to understand the role of HIV in cerebrovascular and neurocognitive outcomes. We therefore conducted a review of publications in PubMed, EMBASE, Web of Science and Wiley Online Library, from inception to April 2021.
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