Publications by authors named "Antonio Soriano-Arandes"
Cancer is not a risk factor for severe COVID-19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.
Pediatr Blood Cancer
August 2024
Article Synopsis
- The EPICO-SEHOP platform in Spain collects COVID-19 data specifically from children, comparing those with cancer or recent stem cell transplants to those without underlying health issues.
- Findings show that children with cancer or who have undergone stem cell transplants generally experience milder COVID-19 symptoms (7.1%) compared to those without comorbidities (14.7%), unless they had a recent transplant (less than 300 days), where 35.7% faced severe illness.
- The shared data aims to inform treatment and isolation strategies, emphasizing the role of collaborative registries in addressing health crises during the pandemic.
Introduction: Childhood pulmonary tuberculosis (TB) remains a diagnostic challenge. This study aimed to evaluate the performance of Xpert Ultra for the diagnosis of pulmonary TB in children in a low TB prevalence setting.
Methods: Prospective, multicentre, diagnostic accuracy study.
Rationale: In 2016, a new interferon-gamma release assay (IGRA) was introduced, QuantiFERON-TB Gold Plus (QFT-Plus), claimed to have improved sensitivity in active tuberculosis (TB).
Objectives: This study aimed to determine the performance of QFT-Plus, compared with previous generation IGRAs and the tuberculin skin test (TST), in children with TB in Europe.
Methods: Multicentre, ambispective cohort study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), a dedicated paediatric TB research network comprising >300 members, capturing TB cases <18 years-of-age diagnosed between January 2009 and December 2019.
Introduction: The QuantiFERON- Gold Plus (QFT-Plus) assay, which features two antigen-stimulated tubes (TB1 and TB2) instead of a single tube used in previous-generation interferon-gamma release assays (IGRAs), was launched in 2016. Despite this, data regarding the assay's performance in the paediatric setting remain scarce. This study aimed to determine the performance of QFT-Plus in a large cohort of children and adolescents at risk of tuberculosis (TB) in a low-burden setting.
View Article and Find Full Text PDFDetection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns.
J Neurovirol
February 2020
Article Synopsis
- A study analyzed urine and amniotic fluid from 138 subjects during a Zika virus outbreak to assess the presence of the virus and its correlation with clinical symptoms and neurological issues in newborns.
- Zika virus was found in a small percentage of symptomatic (11.1%) and asymptomatic (14.7%) women, with neurological problems observed in 13.7% of babies, particularly in those who tested positive for ZIKV.
- The research concluded that clinical symptoms and ZIKV detection in maternal and newborn fluids are not reliable indicators of infection or neurological outcomes in infants during such outbreaks.
Background: Imported malaria is a frequent diagnosis in travellers and migrants. The objective of this study was to describe the epidemiological and clinical characteristics of patients diagnosed with imported malaria within a Spanish collaborative network registering imported diseases (+REDIVI). In addition, the possible association between malaria and type of case, gender, age or area of exposure was explored.
View Article and Find Full Text PDFRationale: The identification of patients with latent tuberculosis infection, who are at higher risk to develop active disease, is an important component of disease control.
Objectives: We aim to compare the usefulness of the QuantiFERON-TB Gold in-tube assay and the tuberculin skin test to predict the development of active tuberculosis during follow-up, using positive and negative predictive values, positive likelihood ratios, and stratified level of risk.
Methods: The study included contacts of tuberculosis cases diagnosed between 2007 and 2009.