Publications by authors named "Antonio Sergio Alves de Almeida"
Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents.
Thiago José Matos-Rocha Maria do Carmo Alves de Lima Anekécia Lauro da Silva Jamerson Ferreira de Oliveira Allana Lemos Andrade Gouveia Antônio Sérgio Alves de Almeida
Rev Inst Med Trop Sao Paulo
April 2017
Introduction:: Schistosomiasis is an infectious parasitic disease caused by trematodes of the genus Schistosoma, which threatens at least 258 million people worldwide and its control is dependent on a single drug, praziquantel. The aim of this study was to evaluate the anti-Schistosoma mansoni activity in vitro of novel imidazolidine derivatives.
Material And Methods:: We synthesized two novel imidazolidine derivatives: (LPSF/PTS10) (Z)-1-(2-chloro-6-fluorobenzyl)-4-(4-dimethylaminobenzylidene)-5-thioxoimidazolidin-2-one and (LPSF/PTS23) (Z)-1-(2-chloro-6-fluoro-benzyl)-5-thioxo-4-(2,4,6-trimethoxy-benzylidene)-imidazolidin-2-one.