Publications by authors named "Antonio Santos-Peral"
The yellow fever 17D vaccine (YF17D) is highly effective but is frequently administered to individuals with pre-existing cross-reactive immunity, potentially impacting their immune responses. Here, we investigate the impact of pre-existing flavivirus immunity induced by the tick-borne encephalitis virus (TBEV) vaccine on the response to YF17D vaccination in 250 individuals up to 28 days post-vaccination (pv) and 22 individuals sampled one-year pv. Our findings indicate that previous TBEV vaccination does not affect the early IgM-driven neutralizing response to YF17D.
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- Dysregulation in myeloid cells, like dendritic cells (DCs) and monocytes, is a common issue in severe COVID-19 cases, and this study explores their behavior in outpatients with mild COVID-19 compared to individuals vaccinated against yellow fever.
- In patients with mild COVID-19, DCs were significantly reduced for several weeks, while YF17D vaccination led to a temporary drop in DCs followed by quick recovery through increased production.
- A subgroup of symptomatic COVID-19 patients displayed abnormalities in CD86 and PD-L1 expression on monocytes and DCs, resembling patterns seen in severely ill patients, highlighting a prolonged dysregulation in immune response even in non-hospitalized cases.