Use of brimonidine before LASIK with femtosecond laser-created flaps for the correction of myopia: a contralateral eye study.

Purpose: To evaluate the changes in the incidence of subconjunctival hemorrhage, hyperemia, photophobia, flap displacements, and flap retractions in myopic patients who have undergone LASIK with an IntraLase 15-kHz femtosecond laser (intraLASIK) with or without the application of brimonidine tartrate 0.2% in one eye.

Methods: Two hundred eyes of 100 myopic patients were enrolled in this brimonidine tartrate fellow eye control study.

Contrast sensitivity after LASIK flap creation with a femtosecond laser and a mechanical microkeratome.

Purpose: To compare the effects on contrast sensitivity of the IntraLase femtosecond laser for flap creation (IntraLASIK) and standard LASIK for myopia.

Methods: Two hundred eyes of 100 consecutive patients underwent LASIK treatment using the VISX S2 laser system. The femtosecond laser (15 kHz IntraLase) was used for flap creation in 100 eyes (50 patients) and a mechanical microkeratome (Carriazo-Barraquer) was used in 100 eyes (50 patients).

Femtosecond laser versus mechanical keratome LASIK for myopia.

Objective: To assess efficacy, safety, predictability, stability, and changes in corneal higher-order aberrations (CHOAs) and contrast sensitivity (CS) after a femtosecond laser for LASIK and standard LASIK for myopia.

Design: Prospective, randomized, comparative clinical study.

Participants: Two hundred eyes of 100 consecutive patients who underwent LASIK treatment using the VISX S2 laser system.

Spherical aberration and contrast sensitivity after cataract surgery with the Tecnis Z9000 intraocular lens.

Purpose: To determine whether implantation of an intraocular lens (IOL) with a modified prolate anterior surface (Tecnis Z9000, AMO) results in reduced spherical aberration and improved contrast sensitivity after cataract surgery.

Setting: Hospital NISA Virgen del Consuelo, Valencia, Spain.

Methods: In an intraindividual randomized prospective study of 30 patients with bilateral cataract, the Tecnis Z9000 IOL was compared with 2 IOLs with spherical surfaces, the AR40e (AMO) and the Stabibag (Ioltech).

Blue-light filtering intraocular lens in patients with diabetes: contrast sensitivity and chromatic discrimination.

Purpose: To evaluate potential changes in contrast sensitivity and color discrimination in diabetic patients who had cataract surgery and implantation of the blue-light filtering AcrySof Natural (SN60AT) intraocular lens (IOL) compared with an ultraviolet-only filtering (AcrySof SA60AT) IOL.

Setting: Refractive Surgery Unit, Hospital NISA Valencia al Mar, Valencia, Spain.

Methods: Forty-four eyes of 22 diabetic patients were enrolled in a blue-light filtering fellow-eye control study.

Corneal aberrations after astigmatic keratotomy combined with laser in situ keratomileusis.

Purpose: To evaluate the optical aberrations in the cornea before and after astigmatic keratotomy (AK) combined with laser in situ keratomileusis (LASIK) in a group of patients with high myopic astigmatism.

Setting: Refractive Surgery Unit, NISA Hospital Virgen del Consuelo, Valencia, Spain.

Methods: Twelve patients (24 eyes) with high myopic astigmatism (from 3.

Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen.

This study was aimed at examining the role of oxygen and nitrogen reactive species in a model of experimental uveitis upon intravitreal injection of bacterial endotoxin to albino New Zealand rabbits. The inflammatory response was evaluated in terms of: (i) the integrity of the blood aqueous barrier (protein and cell content in samples of aqueous humor), (ii) histopathological changes of the eyes, (iii) clinical evaluation (with a score index based on clinical symptoms), and (iv) the concentration of malondialdehyde (MDA), in aqueous humor, as a marker of oxidative stress. Betamethasone was used as reference treatment, superoxide dismutase as quencher of superoxide anion, L-N(G)-nitro-L-arginine-methyl-esther (L-NAME) and chlorpromazine as nitric oxide synthase inhibitors, and ebselen, a glutathione peroxidase mimic, as peroxynitrite reductant.