Lack of diagnostic utility of specific immunoglobulin M in Helicobacter pylori infection in children.

Background: Helicobacter pylori infection results in a systemic immune response characterized by the initial rise of immunoglobulin (Ig) M followed by the elevation of IgG- and IgA-specific antibody levels in serum. Age and regional considerations may modify the accuracy of serological tests.

Objectives: To determine the accuracy of specific IgG, IgA, and IgM in H pylori infection determination in different age groups.