Publications by authors named "Antonio Polito"
Background: Vitreoretinal lymphoma (VRL) still represents a diagnostic challenge for retinal specialists. Early diagnosis and treatment are critical for a better prognosis. Several diagnostic tools have proven helpful in the identification of VRL abnormalities.
View Article and Find Full Text PDFTo study the long-term outcomes of standard ILM peeling and fovea sparing with inverted flap (FSIF) peeling for symptomatic myopic foveoschisis (MF). This retrospective observational study included 36 eyes of 34 consecutive patients who underwent vitrectomy with standard ILM peeling and FSIF peeling for MF between April 2012 and march 2020. The primary outcome measures included best-corrected visual acuity (BCVA) and central foveal thickness (CFT) at 1 month and final visit and postoperative development of macular hole.
View Article and Find Full Text PDFPurpose: To report a longitudinal analysis of specific optical coherence tomography (OCT) features in eyes with diabetic macular edema (DME) treated with anti-VEGF.
Methods: A total of 133 eyes of 103 consecutive patients with center-involving DME were included in the study. The eyes were treated between August 2008 and April 2019 with three monthly intravitreal anti-VEGF injections, either with or without prompt or deferred laser, followed by pro re nata (PRN) re-treatment.
Background: Choroidal neovascularization (CNV) in pregnancy has rarely been described. A differential diagnosis between inflammatory, idiopathic, and myopic CNV may be challenging. Moreover, there is no consensus on management, and therapeutic options may be further limited by patient and physician concerns about potential risk to the fetus.
View Article and Find Full Text PDFPurpose: To evaluate the effectiveness of recombinant tissue plasminogen activator (rtPA) and sulphur hexafluoride gas (SF6) intravitreal injection for the displacement of large submacular haemorrhages (SMH) secondary to neovascular age-related macular degeneration and for guiding the selection of additional treatments or observations for choroidal neovascularization (CNV).
Methods: The medical records of consecutive patients with recent-onset, large SMH, treated at Sacro Cuore Hospital from January 2004 to May 2016, were retrospectively analysed. All eyes underwent a 0.
Morphological changes in the diseased retina on a healthy choroid-retinal pigment epithelial complex after full macular translocation for exudative age-related macular degeneration.
Acta Ophthalmol
March 2019
Purpose: To describe the change in the retinal morphology after full macular translocation (FMT) for exudative age-related macular degeneration (AMD) and identify predictive factors for the visual outcome.
Methods: All patients who underwent FMT from December 2008 through July 2013 were selected. Exclusion criteria were FMT for other disease than AMD, age <60 years, <12 months of follow-up or no available images.
Article Synopsis
- - The study evaluates the long-term effectiveness of intravitreal anti-VEGF treatment for diabetic macular edema (DME) and examines alternative treatments for those with poor responses to the initial therapy.
- - Data from 170 eyes over an average follow-up of about 46 months showed significant improvements in visual acuity and central macular thickness after treatment, with benefits observed for up to five years.
- - For eyes that didn't respond well to anti-VEGF, switching to another anti-VEGF had no significant benefit, but treatments like dexamethasone injections and vitrectomy showed some promise, especially when changed early.
Purpose: To investigate if the contiguity between native and transplanted retinal pigment epithelium (RPE) represents a protective factor against the progression of atrophy after autologous choroidal graft. In addition, the changes in fundus autofluorescence (FAF) in the contiguous and noncontiguous RPE areas were explored.
Methods: The first postoperative reliable FAF image was selected and divided into sectors based on the characteristics of the RPE at the edge of the graft.
Background: Indocyanine Green Angiography (ICG-A) and Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI-OCT) are essential imaging techniques for diagnosis, management and understanding of the pathophysiology of many chorioretinal diseases. Herein, we report the ICG-A and EDI-OCT findings from a case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE), in which these imaging techniques enable the visualization of more diagnostic details than those observable with other widely used diagnostic tools.
Case Presentation: A 60-year-old white female presented with bilateral blurred vision for few days.
Purpose: To investigate the long-term outcome of autologous retinal pigment epithelium -choroid transplantation with a peripheral retinotomy for exudative age-related macular degeneration.
Methods: In a retrospective study, we selected all patients who underwent a retinal pigment epithelium-choroid transplantation from 2007 through 2013. Exclusion criteria were age <60 years, <12 months of follow-up, and retinal pigment epithelium-choroid graft for other diseases than age-related macular degeneration.
Article Synopsis
- - The study aimed to examine the prevalence of vitreomacular adhesion (VMA) in patients with exudative and nonexudative age-related macular degeneration (AMD) compared to age-matched controls, and to track changes in the vitreomacular interface over time.
- - It included a total of 1,067 eyes from subjects at Sacrocuore Hospital over several years, classifying them into three groups: exudative AMD, nonexudative AMD, and no signs of AMD.
- - Findings showed that VMA occurrence was similar across all groups, with spontaneous release (RVMA) being less common in exudative AMD compared to nonexudative AMD, suggesting variations in VMA
Purpose: To compare the results of vitrectomy with complete internal limiting membrane (ILM) removal and inverted ILM flap in the treatment of myopic macular hole (MMH).
Methods: Seventy eyes of 68 patients with MMH undergone pars-plana vitrectomy (PPV) with either complete ILM removal (n = 36, Group 1) or inverted ILM flap technique (n = 34, Group 2) were included in the study. Outcomes measured were the rate of MMH closure assessed by optical coherence tomography (OCT) and visual acuity (BCVA) at six months.
Background: Central Serous Chorioretinopathy (CSC) has been previously reported as an infrequent complication of pregnancy that usually resolves spontaneously after delivery, with minimal or no sequel. We report a case of a severe form of CSC in an uncomplicated pregnancy with extensive subfoveal exudates and severe permanent visual loss. Multimodal imaging techniques, including color and red-free photographs, near-infrared reflectance, fluorescein angiography, and spectral-domain optical coherence tomography, were performed and the findings were correlated to the changes in visual acuity.
View Article and Find Full Text PDFUveal effusion syndrome mimicking severe chronic posterior uveitis: a case series of seven eyes of four patients.
Graefes Arch Clin Exp Ophthalmol
March 2016
Article Synopsis
- The study aimed to describe the clinical features and treatment options for uveal effusion syndrome (UES), which can mimic inflammatory eye diseases, using tailored surgical methods.
- Researchers conducted interventional case studies on seven eyes from four patients diagnosed with UES, employing various diagnostic tools to establish accurate diagnoses and treatment plans.
- Results indicated that surgical interventions effectively resolved detachment and improved vision, highlighting the importance of early diagnosis and personalized treatment to prevent further ocular damage.
Purpose: To investigate the long-term outcome of full macular translocation (FMT) for neovascular age-related macular degeneration (AMD) and to identify predictive factors.
Design: Retrospective, uncontrolled case series.
Participants: Patients were considered for FMT if they had low vision in the fellow eye and choroidal neovascularization (CNV) along with (1) no response to vascular endothelial growth factor (VEGF) inhibitors, (2) retinal pigment epithelium (RPE) tear, (3) subretinal hemorrhage, (4) foveal scar tissue of recent onset, or (5) CNV before the availability of VEGF inhibitors.
Purpose: To evaluate anatomical and visual outcomes following intravitreal dexamethasone implantation (Ozurdex) in eyes with visual loss due to macular edema (ME) secondary to retinal vein occlusion (RVO) and to identify predictive factors for improvement in best-corrected visual acuity (BCVA).
Methods: We retrospectively analyzed medical records of 43 consecutive eyes with treatment-naïve ME secondary to recent onset RVO treated with repeated Ozurdex injections on a pro re nata basis.
Results: The mean follow-up (FU) duration was 14 months (min.
Purpose: The purpose of this study was to evaluate the safety and efficacy of octreotide, a somatostatin analog, for treatment of postsurgical cystoid macular edema.
Methods: Twenty-one patients with chronic, refractory postsurgical cystoid macular edema and Early Treatment Diabetic Retinopathy Study best-corrected visual acuity of 20/25 to 20/400 were randomized 2:1 to 30 mg monthly intramuscular octreotide or placebo. Outcome measures were visual acuity (primary) and macular thickness and fluorescein angiographic leakage (secondary).
Article Synopsis
- The study aimed to explore how posture and other factors impact the daily changes in clinically significant diabetic macular edema (CSDME).
- Ten diabetic patients with CSDME had multiple OCT measurements taken in both upright and recumbent positions throughout the day to assess foveal thickness and various systemic health markers.
- Results showed that foveal thickening decreased more significantly while upright, with improvements in visual acuity, suggesting that posture influences CSDME and may be explained by principles of fluid dynamics.
Purpose: To evaluate the efficacy of pars plana vitrectomy with infracyanine green (IFCG)-assisted internal limiting membrane peeling for the treatment of idiopathic macular hole.
Design: Prospective, noncomparative interventional case series.
Methods: Thirty-eight consecutive eyes of 35 patients with idiopathic macular hole were included in the study.