Synthesis of (-)-Cannabidiol (CBD), (-)-Δ- and (-)-Δ-Tetrahydrocannabinols, Encapsulation of CBD with Nanoparticles for Controlled Delivery and Biological Evaluation.

Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD in solid and hollow pH-sensitive poly(4-vinylpyridine) (solid@p4VP and hollow@p4VP) nanoparticles, and temperature-sensitive poly(N-isopropylacrylamide) (solid@pNIPAM and hollow@pNIPAM) nanoparticles for transport and release CBD in a controlled manner.

In Vitro Antitumor and Anti-Inflammatory Activities of -Derived Compounds Propyl Propane Thiosulfonate (PTSO) and Propyl Propane Thiosulfinate (PTS).

Increasing rates of cancer incidence and the side-effects of current chemotherapeutic treatments have led to the research on novel anticancer products based on dietary compounds. The use of metabolites and extracts has been proposed to reduce the proliferation of tumor cells by several mechanisms. In this study, we have shown the in vitro anti-proliferative and anti-inflammatory effect of two onion-derived metabolites propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO) on several human tumor lines (MCF-7, T-84, A-549, HT-29, Panc-1, Jurkat, PC-3, SW-837, and T1-73).

On the modeling and optimization of two-phase olive-oil washing wastewater treatment and polyphenols recovery by ceramic tubular microfiltration membranes.

This research is focused on modelling and optimization of the performance of a 'green procedure' based on microfiltration (MF) technology, for recovery of high added-value antioxidant compounds (TACs) from two-phase olive-oil washing wastewater (OOWW) and its treatment. Concern of olive oil industry to improve the production process in line with Circular Economy is vital to make it respectful with the environment including the management of the generated effluents. Key operational factors of the MF process were studied, modelled and optimized by multifactorial statistical analysis.

Effect of operating parameters on the physical and chemical stability of an oil gelled-in-water emulsified curcumin delivery system.

Background: Curcumin is a natural antioxidant with important beneficial properties for health, although its low bioavailability and sensitivity to many environmental agents limits its use in the food industry. Furthermore, some studies mention a potential synergistic effect with omega-3 polyunsaturated fatty acids, comprising other bioactive compounds extremely unstable and susceptible to oxidation. A relatively novel strategy to avoid oxidation processes is to transform liquid oils into three-dimensional structures by adding a gelling agent and forming a self-assembled network that can later be vectorized by incorporating it into other systems.

Composition and isolation of goat cheese whey oligosaccharides by membrane technology.

The present research aimed investigates the characterization and concentration of oligosaccharides naturally present in goat cheese whey obtained from two types of goat milk. The goat cheese whey was processed by a two-step cross-flow filtration process and a hydrophilic interaction chromatography - Ultra-Performance Liquid Chromatography coupled to a High Definition Mass Spectrometry. A Quadrupole Time-of-Flight (HILIC UPLC-HDMS-Q-TOF) method was used to identify and measure five different oligosaccharides in the samples.

Analysis of the Flux Performance of Different RO/NF Membranes in the Treatment of Agroindustrial Wastewater by Means of the Boundary Flux Theory.

Dynamic membrane system behaviour must be adequately addressed to avoid process unfeasibility. The lack of proper analysis will mean relying on erroneous permeate flux values in the system design, which will lead to quick and/or steady high fouling rates. In this paper, the authors present additional data supporting the boundary flux theory as a helpful tool for membrane engineers to carefully avoid process failures.

Microwave-assisted extraction for Hibiscus sabdariffa bioactive compounds.

H. sabdariffa has demonstrated positive results against chronic diseases due to the presence of phytochemicals, mainly phenolic compounds. The extraction process of bioactive compounds increases the efficient collection of extracts with high bioactivity.

Development and stability evaluation of water-in-edible oils emulsions formulated with the incorporation of hydrophilic Hibiscus sabdariffa extract.

New functional oils (extra virgin olive oil, EVOO and sunflower oil, SO) containing antioxidants from Hibiscus sabdariffa extract were developed by W/O emulsion. Their physical and chemical stability was measured over time. The lowest coalescence rate was obtained with 8 and 12 wt% surfactant amount for EVOO and SO emulsions, respectively.

Operation setup of a nanofiltration membrane unit for purification of two-phase olives and olive oil washing wastewaters.

In this research work, the purification of olives and olive oil washing wastewaters from two-phase extraction mills by a novel polymeric NF membrane is addressed. The effluent was previously subjected to a physicochemical secondary-tertiary treatment previously optimized at pilot and industrial scales. Within the adequate operating conditions, suspended solids could be completely removed, and the EC was considerable lowered down to good quality values acceptable for irrigation purposes (1.

On the Recent Use of Membrane Technology for Olive Mill Wastewater Purification.

Many reclamation treatments as well as integrated processes for the purification of olive mill wastewaters (OMW) have already been proposed and developed but not led to completely satisfactory results, principally due to complexity or cost-ineffectiveness. The olive oil industry in its current status, composed of little and dispersed factories, cannot stand such high costs. Moreover, these treatments are not able to abate the high concentration of dissolved inorganic matter present in these highly polluted effluents.

Impacts of operating conditions on nanofiltration of secondary-treated two-phase olive mill wastewater.

In the present paper, a thin-film composite polymeric nanofiltration (NF) membrane is examined for the tertiary treatment of secondary-treated two-phase olive mill wastewater, in substitution of the reverse osmosis membrane used in previous work by the Authors. Overcoming the deleterious fouling phenomena persistently encountered in membrane processes managing wastewater streams was indeed pursued. Setting the adequate parameters of the operating variables - that is, operating at ambient temperature upon a net pressure equal to 13 bar (Pc), tangential crossflow in the order of 2.

Physicochemical analysis and adequation of olive oil mill wastewater after advanced oxidation process for reclamation by pressure-driven membrane technology.

Physicochemical characterization of olive mill wastewaters (OMW) was studied after a primary and secondary treatment was implemented in an olive oil factory in Jaén (Spain), comprising natural precipitation, Fenton-like reaction, flocculation-sedimentation and olive stone filtration in series. The application of membrane technology in improving the quality of the secondary-treated OMW (OMW/ST) was examined, to reduce the hazardous electroconductivity (EC) values (2-3 mS cm(-1)). Particle size distribution on OMW/ST shows supra-micron colloids and suspended solids as well as sub-micron particles with a mean size below 1.

A novel photocatalyst with ferromagnetic core used for the treatment of olive oil mill effluents from two-phase production process.

Photocatalytic degradation of olive oil mill wastewater from two-phase continuous centrifugation process was studied. A novel photocatalyst with ferromagnetic properties was characterized and investigated. The degradation capacity of the photocatalytic process of olive oil washing wastewater (OMW) and mixture of olives and olive oil (1 v/v) washing wastewaters (MOMW) was demonstrated.

Performance modeling and cost analysis of a pilot-scale reverse osmosis process for the final purification of olive mill wastewater.

A secondary treatment for olive mill wastewater coming from factories working with the two-phase olive oil production process (OMW-2) has been set-up on an industrial scale in an olive oil mill in the premises of Jaén (Spain). The secondary treatment comprises Fenton-like oxidation followed by flocculation-sedimentation and filtration through olive stones. In this work, performance modelization and preliminary cost analysis of a final reverse osmosis (RO) process was examined on pilot scale for ulterior purification of OMW-2 with the goal of closing the loop of the industrial production process.

Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis.

Oligosaccharides are included among the anti-inflammatory components of milk because of their prebiotic properties and their capacity to act as receptors of microorganisms. Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. Rats were randomly assigned to three different groups.

Absorption of calcium from milks enriched with fructo-oligosaccharides, caseinophosphopeptides, tricalcium phosphate, and milk solids.

Background: Adequate intakes of calcium are required for optimal bone health and protection against chronic disease. Dairy products are an excellent source of calcium.

Objective: The absorption of calcium from a range of fortified milks was measured in humans with the use of stable isotopes.

The administration of a multivitamin/mineral fortified dairy product improves folate status and reduces plasma homocysteine concentration in women of reproductive age.

Background And Objectives: Folate deficiency during the periconceptional period is related to the occurrence and recurrence of neural tube defects. The aim of the study was to assess whether the administration of folic acid and other vitamins and minerals as a fortified dairy product (400 microg per day of folic acid) improves the folate status in women of reproductive age.

Design And Methods: Plasma and red blood cell folate, plasma vitamin E, B12, total plasma homocysteine, plasma lipid profile, and serum ferritin and transferrin levels were investigated in 31 healthy nonpregnant women receiving 500 mL/day of the fortified dairy product for eight weeks.

Cardiovascular effects of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, folic acid, and vitamins E and B6 in volunteers with mild hyperlipidemia.

Objective: Results from epidemiologic studies and clinical trials have indicated that consumption of omega-3 fatty acids, oleic acid, and folic acid have beneficial effects on health, including decreased risk of cardiovascular disease. We evaluated the combined effects of these nutrients through the consumption of milk enriched with omega-3 polyunsaturated fatty acids, oleic acid, vitamins E and B6, and folic acid on risk factors for cardiovascular disease in volunteers with mild hyperlipidemia.

Methods: Thirty subjects ages 45 to 65 y (51.