There is still a role for cytology in the 'liquid biopsy' era. A lesson from a TKI-treated patient showing adenocarcinoma to squamous cell carcinoma transition during disease progression.

Non-small cell lung carcinoma harbouring epidermal growth factor receptor () mutation, usually progress after an initial response to tyrosine-kinase inhibitors (TKI). Liquid biopsy enables with a simple blood draw the accurate detection of p.T790M mutation, the most common resistance mechanism, avoiding the more invasive tissue re-biopsy.

Toward a transdisciplinary approach of ergonomic design for sustainability.

Starting from the results of a theoretical and methodological study on Ergonomic design for sustainability previously developed from the authors, this paper shows the early results of a study that tries to apply them to actual operational and conceptual apparatuses of Ergonomics. In particular, the research aims to verify the possibility for Ergonomics to initiate an update of its current theoretical and procedural tools, towards new design solutions of "sustainable well-being", trying to look for new declinations of its several fields of application. The paper identifies new paradigms and definitions for one of the central themes of ergonomic design, as well as one among the most established and investigated: the usability of products and services.

Strategies and arguments of ergonomic design for sustainability.

Referring to the discussion recently promoted by the Sub-Technical Committee n°4 "Ergonomics and design for sustainability", in this paper will be shown the early results of a theoretical and methodological study on Ergonomic design for sustainability. In particular, the research is based on the comparison between the common thematic structure characterizing Ergonomics, with the principles of Sustainable Development and with criteria adopted from other disciplines already oriented toward Sustainability. The paper identifies an early logical-interpretative model and describes possible and relevant Strategies of Ergonomic design for sustainability, which are connected in a series of specific Sustainable Arguments.

Gallbladder torsion: report of four cases and review of the literature.

Gallbladder torsion is a rare cause of acute acalculous cholecystitis. Preoperative diagnosis is difficult. The treatment of choice remains immediate cholecystectomy.