Publications by authors named "Antonio Losacco"
Chlamydia trachomatis, a human pathogen, is a Gram-negative bacillus and a compulsory intracellular parasite. It is the most common cause of bacterial sexually transmitted infections in both industrialized and developing countries. In women, untreated genital infections can result in devastating consequences such as pelvic inflammatory disease, ectopic pregnancy, and even infertility.
View Article and Find Full Text PDFLactobacilli are members of the normal mucosal microflora of most animals. Probiotic bacteria, such as Lactobacilli, play a major role in the maintenance of a healthy urogenital tract by preventing the colonization of pathogenic bacteria. The potentially probiotic strain Lactobacillus crispatus (ATCC 33820) was investigated for its capacity to influence the innate immune response of HeLa epithelial cells to Candida albicans.
View Article and Find Full Text PDFArticle Synopsis
- Chlamydia pneumoniae is a pathogen that leads to various diseases and often shows treatment resistance even with antibiotics like clarithromycin and ofloxacin.
- Researchers found that natural polyphenols, specifically resveratrol and quercetin, enhance the effectiveness of these antibiotics against Chlamydia pneumoniae, showing significant growth inhibition.
- Additionally, the study indicated that these polyphenols reduced the production of inflammatory markers IL-17 and IL-23 in infected cells, suggesting that combining them with traditional antibiotics may improve treatment outcomes.
Article Synopsis
- Streptococcus pyogenes is a common bacterium found in the throat and nose that can lead to various infections, from mild to severe.
- Lactobacillus plantarum, a probiotic strain, was found to reduce the growth of S. pyogenes and lower levels of inflammatory cytokines IL-17 and IL-23 in human epithelial cell cultures.
- The study suggests that the inhibitory effects of L. plantarum are linked to its ability to downregulate TLR2/4 pathways during S. pyogenes infection.