Publications by authors named "Antonio J Pacheco Palha"
Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.
Jose de Leon Georgios Schoretsanitis Robert L Smith Espen Molden Anssi Solismaa António J Pacheco Palha
Pharmacopsychiatry
March 2022
Article Synopsis
- This international guideline suggests enhancing clozapine package inserts by implementing ancestry-based dosing and titration to reduce adverse drug reactions (ADRs).
- Clozapine, a powerful medication, has a narrow therapeutic range and is highly associated with toxicity, especially in certain populations; it is especially risky due to its high rates of pneumonia-related mortality.
- The guideline outlines six personalized dosing schedules based on ancestry and metabolic activity, recommending varying daily doses of clozapine tailored to individual patient profiles to minimize the risk of ADRs.