Publications by authors named "Antonio J Chemello"
Article Synopsis
- - AB-type toxins consist of an A subunit with enzymatic activity and a B subunit for delivery; typhoid toxin in *Salmonella serovar Typhi* uniquely features two A subunits paired with distinct B subunits (PltB and PltC) for toxin production.
- - Remarkably, another species has independently developed a similar system, producing a different B subunit (PltD) that replaces PltB, showcasing convergent evolution in toxin production.
- - This study emphasizes that the evolution of dual toxin systems can impact virulence, as strains without PltD produce more PltB and are more toxic, suggesting potential avenues for new therapeutic strategies against typhoid fever.
AB-type toxins are a group of secreted protein toxins that are central virulence factors for bacterial pathogens such as and certain lineages of pathogenic and . AB toxins are composed of an active (A) subunit that manipulates host cell biology in complex with a pentameric binding/delivery (B) subunit that mediates the toxin's entry into host cells and its subsequent intracellular trafficking. Broadly speaking, all known AB-type toxins adopt similar structural architectures and employ similar mechanisms of binding, entering and trafficking within host cells.
View Article and Find Full Text PDF