Publications by authors named "Antonio Izarra Santamaria"
Background: We wanted to evaluate if health care for multiple myeloma (MM) patients is equal in different regions of Sweden.
Aim: To study differences in survival for MM depending on health care region and early use of modern treatment.
Methods And Results: Data from the Swedish Myeloma Register from patients diagnosed between 2008 and 2017 was used.
Follow-up of low-risk monoclonal gammopathy of undetermined significance (MGUS) is debated as multiple myeloma (MM) progression risk is low. Worse MM outcome was reported for patients followed for low-risk MGUS, possibly due to less optimal follow-up. However, it is unknown whether progressing low-risk MGUS is associated with aggressive tumor behavior.
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- * Researchers analyzed blood samples from 65 myeloma patients and 65 cancer-free controls, finding consistently lower levels of specific proteins (MCP-3, VEGF, FGF-2, TGF-α) in myeloma patients.
- * The findings suggest that decreasing levels of TGF-α over time could indicate an increased risk of progressing to MM, making it a potential candidate for early detection of the disease.