Publications by authors named "Antonio Guerrero-Sola"
Article Synopsis
- * The variability in disease presentation, particularly in mixed forms of ALS and FTD, complicates the understanding of lipid metabolic alterations and their causal role in the disorders.
- * Recent advancements in lipidomics and other –omics technologies are helping to identify potential biomarkers and clarify the pathological mechanisms underlying these neurodegenerative conditions.
Objective: To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.
Methods: This observational retrospective cross-sectional multicenter study was based on data from the Spanish MG Registry (NMD-ES). Patients were considered refractory when their MG Foundation of America post-interventional status (MGFA-PIS) was unchanged or worse after corticosteroids and two or more other immunosuppressive agents.
Article Synopsis
- Thymoma-associated myasthenia gravis (MG) patients are generally younger and exhibit more severe symptoms compared to those without thymoma, leading to a worse overall prognosis.
- In a study of 964 patients, those with thymoma had higher rates of treatment refractoriness and mortality, particularly among those with nonresectable thymomas.
- Although myasthenic symptoms worsened temporarily in some patients with recurrent thymoma, their long-term prognosis was similar to those with non-recurrent conditions.
Objective: To describe the characteristics of patients with very-late-onset myasthenia gravis (MG).
Methods: This observational cross-sectional multicenter study was based on information in the neurologist-driven Spanish Registry of Neuromuscular Diseases (NMD-ES). All patients were >18 years of age at onset of MG and onset occurred between 2000 and 2016 in all cases.
Introduction: The Notch signalling pathway regulates neuronal survival. It has some similarities with the APP signalling pathway, and competes with the latter for α- and γ-secretase proteolytic complexes. The objective of this study was to study the Notch signalling pathway in the hippocampi of patients with motor neuron disease.
View Article and Find Full Text PDFObjective: To evaluate whether the clinical benefit and relapse rates in anti-muscle-specific kinase (MuSK) myasthenia gravis (MG) differ depending on the protocol of rituximab followed.
Methods: This retrospective multicentre study in patients with MuSK MG compared three rituximab protocols in terms of clinical status, relapse, changes in treatment, and adverse side effects. The primary effectiveness endpoint was clinical relapse requiring a further infusion of rituximab.
Background: Several findings suggest that the amyloid precursor protein (APP) and the amyloid cascade may play a role in motor neuron disease (MND).
Objective: Considering that dementia is one of the most frequent non-motor symptoms in amyotrophic lateral sclerosis (ALS) and that hippocampus is one of the brain areas with greater presence of amyloid-related changes in neurodegenerative diseases, our aim was to analyze the molecular markers of the amyloid cascade of APP in pathology studies of the hippocampus of autopsied patients with ALS and ALS-frontotemporal dementia (FTD).
Methods: We included nine patients with MND and four controls.
Aims: Patients with Fabry disease (FD) characteristically develop peripheral neuropathy at an early age, with pain being a crucial symptom of underlying pathology. However, the diagnosis of pain is challenging due to the heterogeneous and nonspecific symptoms. Practical guidance on the diagnosis and management of pain in FD is needed.
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- The study examines how the subventricular zone (SVZ) behaves in a patient with frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD-ALS).
- An increase in Ki-67 positive cells and neuroblasts indicates heightened cell proliferation in the SVZ, possibly as a response to the neurodegeneration associated with FTLD-ALS.
- This altered neurogenesis might point to new therapeutic strategies to address neuronal loss in ALS.
Meralgia paresthetica is a mononeuropathy affecting the lateral femoral cutaneous nerve that is extremely rare in children. Two adolescent females, aged 11 and 13 years, presented due to tingling and pain on the side of the thigh of 2 to 3 weeks duration. The general examination revealed mild obesity; the neurological examination of both patients is normal except for pain, hypo- or hyperesthesia on the side of the quadriceps.
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