Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide.

Objectives: To investigate how the modulation of the oxidative balance affects cytotoxic therapies in glioblastoma, in vitro.

Material And Methods: Human glioblastoma U251 and T98 cells and normal astrocytes C8D1A were loaded with coenzyme Q10 (CoQ). Mitochondrial superoxide ion (O) and HO were measured by fluorescence microscopy.

Effectiveness of the implementation of a simple radiation reduction protocol in the catheterization laboratory.

Background And Purpose: A reduction in radiation doses at the catheterization laboratory, maintaining the quality of procedures is essential. Our objective was to analyze the results of a simple radiation reduction protocol at a high-volume interventional cardiology unit.

Methods: We analyzed 1160 consecutive procedures: 580 performed before the implementation of the protocol and 580 after it.

CTV to PTV margins for prostate irradiation. Three-dimensional quantitative assessment of interfraction uncertainties using portal imaging and serial CT scans.

Purpose: To determine the magnitude of setup and organ motion errors from a subset of prostate cancer patients treated with conventional conformal radiotherapy, and to estimate the CTV-PTV margin according to published margin recipes.

Methods And Materials: Twenty prostate cancer patients were treated with external radiotherapy using electronic portal images (EPIs). Weekly treatment EPIs and pelvic CT scans were obtained.