Infectious endocarditis caused by fungi, though rare, has a high mortality rate, with Candida and Aspergillus being the most common culprits.
A clinical case presented a woman with unresolved fever, where blood cultures and molecular biology revealed Histoplasma capsulatum as the responsible agent, showing fungal organisms in her heart.
This case underscores the need for improved diagnostic methods, including serology and molecular techniques, in addition to standard blood cultures, to detect invasive fungal infections effectively.