Publications by authors named "Antonio Digito"
Objective: To evaluate a new antimicrobial treatment for central venous catheters in comparison with a traditional treatment, by assessing the catheter colonization and catheter-related bloodstream infection rates in two groups of patients.
Design: Multiple-center, prospective randomized study.
Setting: The medical and surgical departments of ten institutions.
Article Synopsis
- The study aimed to evaluate whether a specific treatment combining plasma filtration and adsorption could enhance blood circulation and immune response in patients with severe septic shock.
- Conducted as a pilot crossover trial with ten patients, the research compared two treatment methods over 10 hours and measured changes in blood pressure, norepinephrine use, and immune response related to TNF-alpha production.
- Results showed that the combined treatment significantly improved mean arterial pressure and reduced norepinephrine requirements, indicating better hemodynamics, while also enhancing the immune system's responsiveness in most patients.