Cardiovascular Effects of a Glycosylated Flavonoids-Rich Leaf Extract from Brazilian : A Potential Health Bio-Input.

: Bioactivity assessments of plant-derived products can benefit human and animal health, especially in regions with vast plant diversity. This study focused on chemical and cardiovascular analyses of A. St.

Phytochemical and antimicrobial evaluation of Triana (Melastomataceae).

Four novel triterpenoid saponins, 1,3,23-trihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester (), 1,3,23-trihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester (), 3---galloyl-1,23-dihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester () and 3---galloyl-1,23-dihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester () and two new pentacyclic triterpenoids, 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid () and 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid (), together with six known compounds were isolated from the ethanolic extracts of leaves and stem bark. Their structures were established by HR-MS, 1D and 2D NMR and comparison with literature data. Additionally, the antimicrobial activity of the leaves and stem bark extracts and fractions was evaluated using the micro broth dilution technique.

Vogel (Fabaceae): phytochemical study and toxicity to Linnaeus (Hymenoptera: Formicidae).

In this work was described the phytochemical investigation of Vogel (Fabaceae) leaves as well as the insecticidal activity of its crude extract and fractions against Linnaeus (Hymenoptera: Formicidae). The phytochemical study led to the identification of α-amyrin, β-amyrin, lupeol, phytol, isomucronulatol and rutin, described for the first time in and mucronulatol. Insecticidal activity was assessed by the ingestion of the crude extract and fractions incorporated into an artificial diet at three different concentrations (0.

A novel ruthenium(ii) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells.

This work describes the synthesis of three new ruthenium(ii) complexes with gallic acid and derivatives of the general formula [Ru(L)(dppb)(bipy)]PF, where L = gallate (GAC), benzoate (BAC), and esterified-gallate (EGA), bipy = 2,2'-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane. The complexes were characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis and IR spectroscopy, and two of them by X-ray crystallography. Cell viability assays show promising results, indicating higher cytotoxicity of the complexes in MDA-MB-231 cells, a triple-negative breast cancer (TNBC) cell line, compared with the hormone-dependent MCF-7 cell line.

Transport of the Ruthenium Complex [Ru(GA)(dppe)]PF into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors.

The triple-negative breast cancer subtype (TNBC) is highly aggressive and metastatic and corresponds to 15-20% of diagnosed cases. TNBC treatment is hampered, because these cells usually do not respond to hormonal therapy, and they develop resistance to chemotherapeutic drugs. On the other hand, the severe side effects of cisplatin represent an obstacle for its clinical use.

Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide.

Antimicrobial peptides (AMPs) are promising candidates for the development of future antibiotics. In an attempt to increase the efficacy of therapeutic AMPs, computer-based design methods appear as a reliable strategy. In this study, we evaluated the antimicrobial efficiency and mechanism of action of a novel designed AMP named PaDBS1R1, previously designed by means of the Joker algorithm, using a fragment of the ribosomal protein L39E from the archaeon Pyrobaculum aerophilum as a template.

Structural and Theoretical Investigation of Anhydrous 3,4,5-Triacetoxybenzoic Acid.

A comprehensive investigation of anhydrous form of 3,4,5-Triacetoxybenzoic acid (TABA) is reported. Single crystal X-ray diffraction, Thermal analysis, Fourier Transform Infrared spectroscopy (FTIR) and DFT calculations were applied for TABA characterization. This anhydrous phase crystallizes in the triclinic [Formula: see text] space group (Z' = 1) and its packing shows a supramolecular motif in a classical [Formula: see text] ring formed by acid-acid groups association.