Cost-effectiveness analysis of the treatment with compressive therapy in the healing of venous ulcers.

Objective: to analyze the cost-effectiveness and calculate the incremental cost-effectiveness ratio of multilayer compressive treatment in relation to inelastic (Unna boot and short stretch) therapy according to the current literature.

Method: quantitative study about cost-effectiveness through modeling with the aid of TreeAge® software for construction of the decision tree. The anticipated assumptions were obtained by using secondary literature data to estimate the cost and effectiveness of the assumed parameters.

Burden of SARS-CoV-2 infection among nursing professionals in Brazil.

Objective: Estimate the burden of SARS-CoV-2 infection among nursing professionals in Brazil.

Method: Ecological study using data from the Nursing Observatory. The weight attributed to diseases was based on the Global Disease Burden Study 2017, considering the lower respiratory infection as moderate.

Effectiveness of the automated drug dispensing system: systematic review and meta-analysis.

Objectives: to compare the effectiveness of the decentralized automated drug dispensing system with pockets.

Methods: an effectiveness study based on a systematic review guided by the question: for patients admitted to hospital units, is the use of automated drug dispensing effective for reducing medication errors when compared to manual unit dose dispensing? The evidence was evaluated by the Grading of Recommendations Assessment, Development and Evaluation and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses instrument, used in the report.

Results: the sample was composed of 15 studies and none of them directly compared both technologies; however, the meta-analysis showed that there is no difference in effectiveness between them [OR 1.

Cost-effectiveness of infusion pumps to reduce errors in a Pediatric ICU.

Objective: To analyze cost-effectiveness and to calculate incremental cost-effectiveness ratio of the use of infusion pumps with drug library to reduce errors in intravenous drug administration in pediatric and neonatal patients in Intensive Care Units.

Methods: Mathematical modeling for economic analysis of the decision tree type. The base case was composed of reference and alternative settings.

[Cost-effectiveness of hepatitis C treatment in slow virologic responders coinfected with HIV].

Recent evidence has demonstrated that slow responders may benefit from antiviral treatment in HCV/HIV coinfection. This study aimed to evaluate the cost-effectiveness of HCV treatment in individuals with genotype 1 coinfected with HIV, with peg-interferon in combination with ribavirin, compared to the inclusion (versus non-inclusion) of slow responders. A Markov model was developed that simulated the progression of liver disease in a hypothetical cohort of one thousand men over 40 years of age, considering the Brazilian Unified National Health System (SUS) perspective and a 30-year timeline.

DNA repair gene expression in biological tissues exposed to low-intensity infrared laser.

Special properties of laser light have led to its usefulness in many applications in therapy. Excitation of endogenous chromophores in biotissues and generation of free radicals could be involved in its biological effects. DNA lesions induced by free radicals are repaired by base excision repair pathway.

[Analysis of Cost-effectiveness of screening for breast cancer with conventional mammography, digital and magnetic resonance imaging].

A cost-effectiveness analysis was conducted in screening for breast cancer. The use of conventional mammography, digital and magnetic resonance imaging were compared with natural disease history as a baseline. A Markov model projected breast cancer in a group of 100,000 women for a 30 year period, with screening every two years.

[Civil construction workers and preventive measures against skin cancer: nursing contribution].

Civil construction's workers are one of the most risk groups to the occupational cancer. The purpose was to identify these workers knowledge about skin cancer and describe protection/prevention measures adopted by them. This is a descriptive and qualitative nature research, developed with 50 workers of a great load building site firm at municipal district of Rio de Janeiro, Brazil.

Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats.

Purpose: To investigate changes in cardiac functional parameters and the cardiac expression of angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1), procollagen type I (proc-I) and transforming growth factor-ß1 (TGF-ß1) in rats irradiated at heart.

Material And Methods: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-ß1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting.