Corollary discharge and anomalous self-experiences in schizophrenia and bipolar disorder: A specificity analysis.

Objective: The Corollary Discharge (CD) mechanism inhibits self-generated speech sound perception, appearing disrupted in schizophrenia and potentially contributing to Anomalous Self-Experiences (ASEs). However, it remains unclear if this alteration and its correlation with ASEs extend to other psychotic disorders.

Methods: Electroencephalography was used to study the N1 Event-Related Potential (ERP) as an index of CD-mediated suppression in the auditory cortex across thirty-five participants with schizophrenia, twenty-six with bipolar disorder, and thirty healthy controls.

Relation between task-related activity modulation and cortical inhibitory function in schizophrenia and healthy controls: a TMS-EEG study.

Schizophrenia has been associated with a reduced task-related modulation of cortical activity assessed through electroencephalography (EEG). However, to the best of our knowledge, no study so far has assessed the underpinnings of this decreased EEG modulation in schizophrenia. A possible substrate of these findings could be a decreased inhibitory function, a replicated finding in the field.

Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia.

Background And Hypothesis: Corollary discharge mechanism suppresses the conscious auditory sensory perception of self-generated speech and attenuates electrophysiological markers such as the auditory N1 Event-Related Potential (ERP) during Electroencephalographic (EEG) recordings. This phenomenon contributes to self-identification and seems to be altered in people with schizophrenia. Therefore, its alteration could be related to the anomalous self-experiences (ASEs) frequently found in these patients.

Corollary discharge function in healthy controls: Evidence about self-speech and external speech processing.

As we speak, corollary discharge mechanisms suppress the auditory conscious perception of the self-generated voice in healthy subjects. This suppression has been associated with the attenuation of the auditory N1 component. To analyse this corollary discharge phenomenon (agency and ownership), we registered the event-related potentials of 42 healthy subjects.

Event-related potentials associated to N-back test performance in schizophrenia.

Mapping of Event-Related Potentials (ERP) associated with auditory and visual odd-ball paradigms has shown consistent differences between healthy controls and schizophrenia patients. It may be hypothesized that higher task attentional/cognitive demand will result in larger differences in these paradigms, which may help understanding the substrates of cognitive deficits in this syndrome. To this aim, we performed an EEG study comparing the effects of increasing the attentional/cognitive load of an auditory N-back task on the Event-Related Potential in 50 subjects with schizophrenia (11 first episodes) and 35 healthy controls.

Neurobiological underpinnings of cognitive subtypes in psychoses: A cross-diagnostic cluster analysis.

Schizophrenia and bipolar disorder include patients with different characteristics, which may hamper the definition of biomarkers. One of the dimensions with greater heterogeneity among these patients is cognition. Recent studies support the identification of different patients' subgroups along the cognitive domain using cluster analysis.

Attention-deficit/hyperactivity disorder in children and adolescents: An event-related potential study of working memory.

Working memory (WM) impairments have been frequently observed as an important feature of attention-deficit/hyperactivity disorder (ADHD). Event-related potential (ERP) differences between ADHD and healthy controls (HC) would be expected during WM task performance. Especially, the so-called slow wave (SW), which is related to the retention process, might present amplitude differences in ADHD.

Neurophysiological differences between ADHD and control children and adolescents during the recognition phase of a working memory task.

Impairment of executive functions including attention and working memory (WM) have been proposed as an important feature of Attention Deficit and Hyperactivity Disorder (ADHD). During the recognition phase of a delayed match-to-sample test (DMTS) a reduced N2pc component, related to the attentional selection of the memorized item and a reduced distractor positivity (Pd), related to the processing suppression of distractors are expected in ADHD subjects. For the purpose of the study, twenty-nine ADHD subjects diagnosed with a structured interview and the DuPaul questionnaire, were included in the study.

Frequency coupling of low and high frequencies in the EEG of ADHD children and adolescents in closed and open eyes conditions.

The present report examines the possible differences in absolute Power Spectral Density (PSD), the topography of brain rhythms, and low frequency (delta and theta) vs. beta PSD when attention deficit disorder (ADHD) children and controls are compared. These results would potentially be useful to test the validity of the developmental lag and differential developmental models for ADHD.

Event related potentials changes associated with the processing of auditory valid and invalid targets as a function of previous trial validity in a Posner's paradigm.

The present study tries to analyze the neural basis of the so-called "Inter-trial Validity-Invalidity Effects" by means of Event-Related Potentials. The N1, P2, P3a and P3b components were examined. The aim is to show the sequential effects on Event-Related Potentials by analyzing the effect of previous trial condition (n-1) in the processing of current trial target (n).