Publications by authors named "Antonio Andrea Grosso"
Background: Over the past decade, the range of surgical options to benign prostatic obstruction (BPO) has expanded significantly with the advent of minimally invasive surgical therapies (MISTs). Nevertheless, the available evidence in the field is heterogeneous. Efficacy and safety thresholds are yet to be determined.
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- The European Association of Urology (EAU) developed guidelines during the COVID-19 pandemic to prioritize surgeries for patients with urological malignancies, focusing on "high-risk" cases.
- A study compared tumor characteristics of patients treated during the pandemic (2020-2021) with those treated post-pandemic (2022-2023), finding that while surgical procedures were similar, certain surgeries like radical prostatectomies and partial nephrectomies were significantly lower during the pandemic.
- Despite the differences in surgery rates, the study found no significant changes in tumor pathological features, indicating that effective prioritization and centralization of care can help maintain the quality of oncological treatment during health crises.
Purpose: To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) for highly-complex renal masses (PADUA ⩾ 10) with versus without the use of 3DVMs.
Materials And Methods: We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Only PADUA ⩾ 10 cases were considered eligible for analysis.
Purpose: To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) with vs without the use of three-dimensional virtual models (3DVMs).
Methods: We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Propensity score matching analysis (PSMA) was applied.
Introduction: Benefits and harms of avoid the sent placement during IntraCorporeal Neobladder configuration are still debated. Our objective was to describe the step-by-step technique of Florence intracorporeal neobladder (FloRIN) configuration performed with stentless procedure focusing on perioperative and mid-term functional outcomes.
Materials And Methods: In this single institution prospective randomized 1:1 series all consecutive patients underwent Robot-Assisted Radical Cystectomy (RARC) and FloRIN reconfiguration from January 2021 to March 2021 were enrolled.
Minimally invasive transperitoneal partial versus radical nephrectomy in obese patients: perioperative and long-term functional outcomes from a large perspective contemporary series (RECORd2 project).
Minerva Urol Nephrol
April 2024
Article Synopsis
- - This study analyzes outcomes of laparoscopic (LPN), robot-assisted (RAPN), and laparoscopic radical nephrectomy (LRN) in obese patients with renal cell carcinoma to assess their perioperative and long-term effectiveness.
- - Data from 388 patients were evaluated, showing that LRN resulted in a significantly higher incidence of acute kidney injury and greater decline in renal function compared to LPN and RAPN.
- - The research suggests that LPN and RAPN are associated with similar complication rates and better kidney function preservation than LRN, emphasizing the advantages of these minimally invasive techniques for obese patients.
Article Synopsis
- The study aimed to determine if delays in surgery for prostate cancer patients undergoing robot-assisted radical prostatectomy (RARP) are linked to a higher likelihood of cancer progression (pathological upstaging).
- A total of 2017 patients with various risk categories for prostate cancer were analyzed, finding that the average time from diagnosis to treatment varied by risk level, with localized high-risk patients experiencing delays.
- Results indicated that delays in surgery, particularly for localized high-risk cases, could increase the risk of worse pathological outcomes, suggesting timely intervention is important.
Article Synopsis
- The study aimed to evaluate the outcomes of the stentless FloRIN technique used during Robot-Assisted Radical Cystectomy (RARC) for bladder reconstruction, focusing on perioperative and mid-term results.
- A total of 63 patients participated, with half receiving the stentless procedure; results showed shorter operation times and hospital stays for those without stents, while complications were similar between both groups.
- The findings suggest that the stentless FloRIN technique is a safe and effective option for bladder reconstruction, demonstrating comparable functional outcomes regarding kidney health over a six-month follow-up.
Article Synopsis
- A study compared the outcomes of two surgical treatments for benign prostatic hyperplasia (BPH): en-bloc HoLEP and robot-assisted simple prostatectomy (RASP), analyzing data from two medical centers over five years.
- After matching patients based on specific criteria, results showed that HoLEP had shorter operative time, hospitalization, and lower complication rates than RASP, while RASP had better outcomes for antegrade ejaculation and urinary flow.
- Despite these differences, both procedures had similar success rates (Trifecta rate), indicating that both methods are effective options for treating BPH.
Purpose: Aim of the present study was to develop and validate a nomogram to accurately predict the risk of chronic kidney disease (CKD) upstaging at 3 years in patients undergoing robot-assisted partial nephrectomy (RAPN).
Methods: A multi-institutional database was queried to identify patients treated with RAPN for localized renal tumor (cT1-cT2, cN0, cM0). Significant CKD upstaging (sCKD-upstaging) was defined as development of newly onset CKD stage 3a, 3b, and 4/5.
Background: The role of redo partial nephrectomy (PN) for recurrent renal cell carcinoma (RCC) is still overlooked.
Objective: To report our experience of salvage PN for local recurrence after previous nephron-sparing surgery (NSS).
Design Setting And Participants: We prospectively gathered data from patients treated with robotic redo PN for locally recurrent RCC after previous NSS from January 2017 to January 2023.
Background: The aging population and the incidence of renal cell carcinoma (RCC) are increasing worldwide. Over 25% of newly diagnosed LRM (localized renal masses) occur in patients over the eighth decade of life. The decision-making and treatment approach to LRM in this population represents a clinical dilemma due to inherited decreased functional reserve and competing mortality risks.
View Article and Find Full Text PDFIntroduction: The aim of the study was to investigate clinical and surgical factors associated with early catheter replacement in patients treated with Holmium Laser Enucleation of the Prostate (HoLEP).
Materials And Methods: Data of patients treated with HoLEP at our Institution by a single surgeon from March 2017 to January 2021 were collected. Preoperative variables, including non-invasive uroflowmetry and abdominal ultrasonography (US), were recorded.
Background: There is a lack of evidence on acute kidney injury (AKI) and new-onset chronic kidney disease (CKD) after surgery for localised renal masses (LRMs) in patients with two kidneys and preserved baseline renal function.
Objective: To evaluate the prevalence and risk of AKI and new-onset clinically significant CKD (csCKD) in patients with a single renal mass and preserved renal function after being treated with partial (PN) or radical (RN) nephrectomy.
Design Setting And Participants: We queried our prospectively maintained databases to identify patients with a preoperative estimated glomerular filtration rate (eGFR) of ≥60 ml/min/1.
Introduction: We assessed the efficacy and safety of holmium laser enucleation of the prostate (HoLEP) in patients with high comorbidity burden.
Materials And Methods: Data from patients treated with HoLEP at our academic referral center from March 2017 to January 2021 were prospectively collected. Patients were divided according to their CCI (Charlson Comorbidity Index).
Article Synopsis
- A computer program called Watson Elementary (WE) helps doctors find prostate cancer more accurately using special images called mpMRI.
- The study looked at patients who had surgery for prostate cancer to see how well WE did in identifying cancer locations and sizes.
- WE was found to be very good at detecting cancer, showing better results in many cases compared to traditional methods.
Purpose: The present study sought to provide reproducible and patient-oriented metrics to assess the rate of "successful" outcomes (Trifecta) following holmium laser enucleation of the prostate (HoLEP). Clinical and surgical predictors of failure to achieve Trifecta were investigated.
Materials And Methods: We queried our prospectively collected database of all patients treated with HoLEP between March 2017 and January 2021.
Introduction: The clinical management of pT3a pathologic-upstaged renal cell carcinoma (RCC) patients is actually controversial. Aim of this study was i) to assess the impact of pT3a upstaging on oncologic outcomes after robot-assisted partial nephrectomy (RAPN) for cT1-T2 RCC; ii) to explore clinical and surgical predictors of pT3a upstaging; iii) to evaluate the differential impact of perinephric fat invasion (PFI) or sinus fat invasion (SFI) on survival outcomes after RAPN in case of upstaged pT3a RCC.
Materials And Methods: Clinical and surgical data from consecutive RCCs treated with RAPN in a single referral centre between January 2017 and June 2021 were prospectively collected and retrospectively reviewed.