The Implementation of a Mobile APP for Cancer Care Management at the Brazilian National Cancer Institute.

There is increasing recognition of the potential to use mobile health (mHealth) technologies such as smartphone apps to support clinical care. Mobile apps are progressively being implemented to manage chronic diseases like cancer to improve patient care. The app deployed at the Brazilian National Cancer Institute enables patients to access the appointments/exam booking, medication prescription, and cancer-prevent educational resources, improving self-management, autonomy, and cancer treatment outcomes in resource-limited environments.

Radiotherapy Information System in Cancer Treatment Improvement: A Case Study at the Brazilian National Cancer Institute.

Radiotherapy is one of the main means of treating cancer patients. Its application has grown worldwide. Around 50% of all cancer patients should receive radiation.

Innovation in Cancer Treatment: The Impacts of Robotic-Assisted Surgery Adoption at the Brazilian National Cancer Institute.

Robotic-assisted surgery has been actively applied in several fields of minimally invasive surgery, and its use in cancer treatment is increasing. This technology has diffused rapidly, despite high costs and limited reimbursement. Studies have proven the positive results of robotic surgery for patients' quality of life.

Implementation of a pharmacogenomic program in a Brazilian public institution.

This narrative review describes implementation, current status and perspectives of a pharmacogenomic (PGx) program at the Brazilian National Cancer Institute (INCA), targeting the cancer chemotherapeutic drugs - fluoropyrimidines, irinotecan and thiopurines. This initiative, designed as a research project, was supported by a grant from the Brazilian Ministry of Health. A dedicated task force developed standard operational procedures from recruitment of patients to creating PGx reports with dosing recommendations, which were successfully applied to test 100 gastrointestinal cancer INCA outpatients and 162 acute lymphoblastic leukemia pediatric patients from INCA and seven other hospitals.

Implementing an Oncology Decision Support System: The Case of the Brazilian National Cancer Institute.

Brazil has a complex situation in cancer treatment services. The incidence rates have reached around 600.000 new cases each year.

Decision Support System for Inventory Management in Healthcare Organizations: A Case Study at the Brazilian National Cancer Institute.

Nowadays, the great majority of the healthcare organizations has been criticized due to the high costs and low efficiency and are facing a critical situation aggravated by unmet demand and aging population. Availability of medicines is one of the clearest indicators that a healthcare organization is working efficiently. Medicines represent a large portion of the costs in the health services due to the significant value of these products and their storage and control requirements.

Decision Support Systems in Cancer Treatment: A Case Study at Brazilian National Cancer Institute.

Nowadays Brazil has a complex cancer care scenario. There are nearly 600.000 new cancer cases each year in Brazil, and the huge majority of patients have some contact with hospital services.

Smart Oncology Care Networks: An Approach in Information Systems to Support Brazilian National Cancer Institute.

In last decades Information Technology (IT) has been established as the main tool to support processes. Medical area has noticed the opportunity for improvement and interacting with IT has enabled solid interdisciplinary instruments for improvement. The aim in this project is composed by an analysis of the relationship between the application of information technologies, oncological assistance and innovation.

Knowledge Management for Brazilian Cancer Care Services.

Nowadays Brazil has a complex cancer care scenario. There are nearly 600.000 new cancer cases each year in Brazil, and the huge majority of patients have some contact with hospital services.

Mobile Technology Applications in Cancer Palliative Care.

Mobile devices frequently used in other specialties can find great utility in palliative care. For healthcare professionals, the use of mobile technology not only can bring additional resources to the care, but it can actually radically change the cancer remote care practices. The Brazilian National Cancer Institute (INCA) has developed the largest cancer home care program in Latin America, which currently benefits more than 500 patients.

Big Data in Brazilian Cancer Surveillance.

Cancer research has a great importance across the world. It is responsible for data analysis of cancer incidence by region, ethnicity, gender, age, social and economic issues, and contributes to the assessment of population health necessities. Nowadays, Brazil has a complex cancer care scenario.

Influence of a Brazilian wild green propolis on the enamel mineral loss and Streptococcus mutans' count in dental biofilm.

Objective: This study investigated the anti-demineralizing and antibacterial effects of a propolis ethanolic extract (EEP) against Streptococcus mutans dental biofilm.

Design: Blocks of sound bovine enamel (n=24) were fixed on polystyrene plates. S.

Quality of Life related to Eruption Hematoma in a Twenty Months Old Infant.

Aim: This paper describes a case of an eruption hematoma in a 20-month-old boy and the impact of this hematoma on the quality of life (QoL) related to oral health of this infant and his family.

Background: Eruption hematoma is a soft benign cyst that contains blood and overlie a tooth that are about to erupt. Oral health conditions can affect the QoL and bring psychological impacts.

Does the presence of sucrose in pediatric antibiotics influence the enamel mineral loss and the Streptococcus mutans counts in dental biofilm?

The role of antibiotics containing sucrose on the formation of dental caries is still controversial. This study aimed to investigate the effect of two antibiotics (amoxicillin and potassium clavulanate suspension), with and without sucrose, on human dental hardness and Streptococcus mutans counts in dental biofilm. Primary tooth fragments (n=72) were coated with nail varnish leaving a window of 2.

Influence of oral rehabilitation on the oral health-related quality of life of a child with ectodermal dysplasia.

Ectodermal dysplasia (ED) is a rare congenital hereditary disorder among a group of syndromes characterized by abnormalities of ectodermic structures. The purpose of this report is to compare the oral health-related quality of life (OHRQoL) before and after complete oral rehabilitation of a five-year-old boy with ED. Delivery of upper and lower dentures resulted in immediate improvement of the child's OHRQoL.

Oral bacteria adherence to suture threads: an in vitro study.

Purpose: This study investigated the adherence of oral microorganisms to different types of suture threads.

Methods: Pieces of thread were distributed on 24-well plates, according to the following groups: (G1) nylon, (G2) silk, (G3) polyglactin 910, (G4) polyglactin 910 with triclosan. Blank control (G5) consisted of one thread from each group.

Clinical and genetic analysis of a nonsyndromic oligodontia in a child.

The etiology of tooth agenesis may be related to several factors, among them, the genetic alterations that play a fundamental role in the development of this dental anomaly, so that knowledge about it helps the clinician to have a greater understanding of their patients. Thus, the aim of this study was to report the case of a nonsyndromic child, with tooth agenesis of one premolar, three first permanent molars, and all second permanent molars. In addition, a genetic research between polymorphic variants in genes MMP3 and BMP2 was performed in order to observe the association between changes in these genes and congenital tooth absences.

[Factors affecting the adoption of ICT tools in experiments with bioinformatics in biopharmaceutical organizations: a case study in the Brazilian Cancer Institute].

The scope of this article is to identify and analyze the factors that influence the adoption of ICT tools in experiments with bioinformatics at the Brazilian Cancer Institute (INCA). It involves a descriptive and exploratory qualitative field study. Evidence was collected mainly based on in-depth interviews with the management team at the Research Center and the IT Division.

In vitro effect of paediatric liquid medicines on deciduous enamel exposed to biofilm.

Objective: This study aimed to assess the in vitro effects of paediatric liquid medicines on deciduous enamel exposed to biofilms.

Methods: Fragments (n = 25) of first primary molars were covered by nail varnish, leaving a 22 mm(2) exposure area. Specimens were fixed in polystyrene plates containing BHI broth media.

Effect of Coffea canephora aqueous extract on microbial counts in ex vivo oral biofilms: a case study.

In the present study, the ex vivo antimicrobial effect of brewed coffee was tested on oral biofilms. For this, unsweetened and sweetened (10 % sucrose) brewed light-roasted Coffea canephora at 20 % was used in biofilms formed by non-stimulated saliva from three volunteers. After 30 min contact with unsweetened and sweetened brews, the average microorganism count in the biofilms reduced by 15.

Caries preventive effects of xylitol-based candies and lozenges: a systematic review.

Objective: A systematic review of published data was conducted with the aim of assessing the caries preventive effect of consuming xylitol-based candies and lozenges.

Methods: Electronic and hand searches were performed to find clinical trials concerning the consumption of products containing xylitol, published up to November 2009. The studies must have had the following characteristics: (a) a comparison of caries progression in subjects who either did or did not consume candies or lozenges containing xylitol during a minimum follow-up period of 1 year; and (b) a concurrent comparison of the percentage of caries progression according to the World Health Organization criteria.

The importance of dental care for a child with severe congenital neutropenia: a case report.

Congenital neutropenia is characterized by a decrease in the absolute number of circulating neutrophils and an increased susceptibility to infections. This paper describes the case history of a child with severe congenital neutropenia who had aggressive periodontitis associated with generalized carious lesions. She had Kostmann syndrome, which is associated with recessive mutation of the HAX-1 gene.

Self-inflicted oral injury in an infant with transverse myelitis.

Acute transverse myelitis (ATM) is an inflammatory disorder that affects the spinal cord. It is characterized by signs and symptoms of neurologic dysfunction in the motor and sensory tracts of the spinal cord bilaterally, resulting in weakness, sensory loss, and autonomic dysfunction with acute or subacute onset. We report on a child who had ATM and respiratory distress requiring ventilatory assistance who presented with severe self-mutilation involving his lips.

Effects of metformin on QT and QTc interval dispersion of diabetic rats.

Background: Several drugs can cause prolonged QT interval, as well as prolonged QT dispersion (QTd) in electrocardiographic (EKG) recordings. QTd may be a potentially sensitive marker of increased risk of cardiac arrhythmias and sudden cardiac death. Metformin is an effective antihyperglycemic agent used in the treatment of diabetes.

Pseudomonas aeruginosa in the Early Childhood: A Case Report.

Pseudomonas aeruginosa is an opportunistic bacterium that usually affects immunocompromised patients, causing infections whose signals and symptoms are related to the affected organ. The patient presented in this article was infected when he was 9 months old. Such condition led to certain alterations like dental improperly positioned teeth, retained deciduous teeth, hipodonty of permanent teeth, atrophy of the upper jaw and dental crowding.